RGS3 and SCN5A

Number of citations: 54 (PubMedID 16637659)
Data Source: HPRD (in vitro)

		RGS3	SCN5A
Name		regulator of G protein signaling 3	sodium voltage-gated channel alpha subunit 5
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane	Voltage-gated Sodium Channel Complex Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Membrane Lateral Plasma Membrane Z Disc T-tubule Monoatomic Ion Channel Complex Sarcolemma Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Calmodulin Binding Fibroblast Growth Factor Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Ubiquitin Protein Ligase Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Bundle Of His Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential Voltage-gated Sodium Channel Activity Involved In SA Node Cell Action Potential Scaffold Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction	Regulation Of Heart Rate Cardiac Conduction System Development Cardiac Ventricle Development Brainstem Development Monoatomic Ion Transport Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Response To Denervation Involved In Regulation Of Muscle Adaptation Telencephalon Development Cerebellum Development Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Action Potential Positive Regulation Of Epithelial Cell Proliferation Membrane Depolarization Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cellular Response To Calcium Ion Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential AV Node Cell Action Potential Bundle Of His Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Membrane Depolarization During Bundle Of His Cell Action Potential AV Node Cell To Bundle Of His Cell Communication Regulation Of Heart Rate By Cardiac Conduction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport
Pathways		G alpha (q) signalling events G alpha (i) signalling events	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		None	Indecainide Ranolazine Phenytoin Topiramate Disopyramide Lidocaine Valproic acid Mexiletine Hexylcaine Cinchocaine Mephenytoin Lamotrigine Carbamazepine Moricizine Riluzole Prilocaine Ethotoin Oxcarbazepine Benzonatate Cocaine Quinidine Zonisamide Procainamide Tocainide Promethazine Chloroprocaine Propafenone Flecainide Encainide Fosphenytoin Quinidine barbiturate Ajmaline Aprindine Dronedarone Brivaracetam Vernakalant Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Isavuconazole Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases		None	Atrial fibrillation Sick sinus syndrome (SSS); Sinus node dysfunction Familial idiopathic ventricular fibrillation Brugada syndrome (BRS) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Height ( 28552196 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 )	Atrial fibrillation ( 29892015 30061737 ) Brugada syndrome ( 35210625 32619740 23872634 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic conduction measures ( 23463857 19389651 ) Electrocardiographic traits ( 20062063 ) Electrocardiographic traits (multivariate) ( 32602732 ) Global electrical heterogeneity phenotypes ( 29622589 ) P wave duration ( 24850809 28794112 ) PR interval ( 21347284 32439900 29127183 30046033 20062060 25035420 23139255 31217584 ) PR segment duration ( 24850809 ) QRS duration ( 31217584 31251759 27577874 25035420 21076409 ) QT interval ( 29213071 29874175 19305408 24952745 19305409 ) Resting heart rate ( 27798624 ) Supraventricular ectopy ( 29618737 ) T wave morphology restitution during exercise ( 31607149 ) T wave morphology restitution during exercise (MTAG) ( 31607149 ) T wave morphology restitution during recovery from exercise ( 31607149 ) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149 ) TPE interval (resting) ( 32386560 )
Interacting Genes		24 interacting genes: ACD APP CNKSR2 CYSRT1 DEPDC1B EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PAX6 PLSCR1 PRKN SCN5A YWHAB YWHAE YWHAQ YWHAZ	23 interacting genes: ANKS1A BANP CALM1 CBL CDK2 CRYAB DLG1 DLG2 DLG3 DLG4 EMC9 NEDD4 NEDD4L PATJ RGS2 RGS3 SNTA1 SNTB1 SNTB2 SNTG2 TEKT4 WWP2 ZMYND19
Entrez ID		5998	6331
HPRD ID		03720	02543
Ensembl ID		ENSG00000138835	ENSG00000183873
Uniprot IDs		A0A087WUY2 A0A8Q3WKG2 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3	E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90
PDB IDs		2F5Y 2OJ4 3FBK	2KBI 2L53 4DCK 4DJC 4JQ0 4OVN 5DBR 6LQA 6MUD 7DTC 7L83 8VYJ 8VYK
GO Terms Enriched among Interactors		Phosphoserine Residue Binding Enzyme Binding G Protein-coupled Receptor Binding Ephrin Receptor Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Developmental Process Protein Domain Specific Binding Regulation Of Spontaneous Synaptic Transmission Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Membrane Potential Ligand-gated Ion Channel Signaling Pathway Protein Sequestering Activity Signal Transduction Regulation Of Transport Protein Kinase Binding Negative Regulation Of Protein Localization To Nucleus Transmembrane Transporter Binding Modulation Of Excitatory Postsynaptic Potential Regulation Of Monoatomic Ion Transmembrane Transport Peptidase Activator Activity System Development Cellular Response To Manganese Ion Extracellular Exosome Ubiquitin Protein Ligase Binding Regulation Of Establishment Of Protein Localization Glutamatergic Synapse Regulation Of MiRNA Transcription Response To Manganese Ion Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Targeting Regulation Of Protein Localization Negative Regulation Of Protein Localization Response To Lead Ion Negative Regulation Of RNA Biosynthetic Process Regulation Of Monoatomic Ion Transport Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Catecholamine Stimulus Regulation Of Protein Transport Regulation Of Neurotransmitter Uptake Response To Catecholamine Focal Adhesion Guanyl Nucleotide Binding Startle Response Negative Regulation Of Transport Regulation Of Innate Immune Response Positive Regulation Of Protein Transport Melanosome Negative Regulation Of Macromolecule Metabolic Process G-protein Beta/gamma-subunit Complex Binding	Ionotropic Glutamate Receptor Binding Regulation Of Potassium Ion Export Across Plasma Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Dystrophin-associated Glycoprotein Complex Transmembrane Transporter Binding Cytoplasm Negative Regulation Of Potassium Ion Export Across Plasma Membrane Neuromuscular Junction Potassium Channel Inhibitor Activity Negative Regulation Of Transmembrane Transport Receptor Localization To Synapse Receptor Clustering Negative Regulation Of Transport Regulation Of Monoatomic Cation Transmembrane Transport Protein Localization To Synapse Regulation Of Membrane Potential Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Or Maintenance Of Cell Polarity Plasma Membrane Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Structural Molecule Activity PDZ Domain Binding Protein Localization To Cell Junction Regulation Of Potassium Ion Transport Regulation Of Metal Ion Transport Negative Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transport Kinase Binding Syntrophin Complex Postsynaptic Density Membrane Regulation Of Monoatomic Ion Transport Sarcolemma Regulation Of Transport Neuroligin Family Protein Binding Regulation Of Sodium Ion Transmembrane Transport Muscle System Process Protein Kinase Binding Sodium Channel Inhibitor Activity Protein Monoubiquitination GMP Kinase Activity Neuron Projection Synaptic Membrane GDP Metabolic Process Adherens Junction