RGS3 and GNA11

Number of citations of the paper that reports this interaction (PubMedID 9858594)
37

Data Source:
HPRD (in vivo, in vitro)

		RGS3	GNA11
Description		regulator of G protein signaling 3	G protein subunit alpha 11
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Membrane Synapse Extracellular Exosome
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding Enzyme Regulator Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction	Skeletal System Development Action Potential Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Heart Development Phototransduction, Visible Light Regulation Of Blood Pressure Entrainment Of Circadian Clock Positive Regulation Of Insulin Secretion Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH Endothelin Receptor Signaling Pathway Cranial Skeletal System Development Ligand-gated Ion Channel Signaling Pathway
Pathways		G alpha (q) signalling events G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Diseases
GWAS		Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)	Asthma ( 31959851)
Interacting Genes		24 interacting genes: ACD APP CNKSR2 CYSRT1 DEPDC1B EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PAX6 PLSCR1 PRKN SCN5A YWHAB YWHAE YWHAQ YWHAZ	17 interacting genes: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A NHERF1 PTGIR RGS14 RGS3 TBXA2R TRPC3 TSHR
Entrez ID		5998	2767
HPRD ID		03720	00759
Ensembl ID		ENSG00000138835	ENSG00000088256
Uniprot IDs		A0A087WUY2 A0A8Q3WKG2 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3	P29992
PDB IDs		2F5Y 2OJ4 3FBK	6OIJ 7RKF 7TRY 7XXH
Enriched GO Terms of Interacting Partners?		Phosphoserine Residue Binding Enzyme Binding G Protein-coupled Receptor Binding Ephrin Receptor Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Developmental Process Protein Domain Specific Binding Regulation Of Spontaneous Synaptic Transmission Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Membrane Potential Ligand-gated Ion Channel Signaling Pathway Protein Sequestering Activity Signal Transduction Regulation Of Transport Protein Kinase Binding Negative Regulation Of Protein Localization To Nucleus Transmembrane Transporter Binding Modulation Of Excitatory Postsynaptic Potential Regulation Of Monoatomic Ion Transmembrane Transport Peptidase Activator Activity System Development Cellular Response To Manganese Ion Extracellular Exosome Ubiquitin Protein Ligase Binding Regulation Of Establishment Of Protein Localization Glutamatergic Synapse Regulation Of MiRNA Transcription Response To Manganese Ion Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Targeting Regulation Of Protein Localization Negative Regulation Of Protein Localization Response To Lead Ion Negative Regulation Of RNA Biosynthetic Process Regulation Of Monoatomic Ion Transport Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Catecholamine Stimulus Regulation Of Protein Transport Regulation Of Neurotransmitter Uptake Response To Catecholamine Focal Adhesion Guanyl Nucleotide Binding Startle Response Negative Regulation Of Transport Regulation Of Innate Immune Response Positive Regulation Of Protein Transport Melanosome Negative Regulation Of Macromolecule Metabolic Process G-protein Beta/gamma-subunit Complex Binding	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Smooth Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Vascular Process In Circulatory System Circulatory System Process G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of System Process Signal Transduction Vasoconstriction Plasma Membrane Muscle Contraction Regulation Of Blood Circulation Muscle System Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Inorganic Ion Homeostasis Membrane System Process Regulation Of Vasoconstriction Vascular Associated Smooth Muscle Contraction Regulation Of Cell Communication Regulation Of Signaling Endothelin Receptor Activity Calcium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of MAPK Cascade Calcium Ion Homeostasis Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol Biosynthetic Process Gq/11-coupled Serotonin Receptor Activity Calcium Ion Transport Regulation Of Muscle System Process Regulation Of Intracellular Signal Transduction Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of Intracellular Signal Transduction Renal Albumin Absorption G Protein-coupled Serotonin Receptor Complex Regulation Of ERK1 And ERK2 Cascade Ameboidal-type Cell Migration Positive Regulation Of Multicellular Organismal Process Type 1 Angiotensin Receptor Binding Chemical Homeostasis Renal Absorption
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?