REV3L and REV1

Number of citations of the paper that reports this interaction (PubMedID 15189446)
0

Data Source:
HPRD (two hybrid)

		REV3L	REV1
Description		REV3 like, DNA directed polymerase zeta catalytic subunit	REV1 DNA directed polymerase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Zeta DNA Polymerase Complex Nuclear Lumen	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	DNA Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Deoxycytidyl Transferase Activity Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response Translesion Synthesis Error-prone Translesion Synthesis	DNA Metabolic Process DNA Replication DNA Repair DNA Damage Response Response To UV Error-prone Translesion Synthesis Error-free Translesion Synthesis DNA Biosynthetic Process
Pathways		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 23128233 28067908) Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 26414677) Psoriasis ( 25574825) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549) Ulcerative colitis ( 28067908)	Bipolar disorder ( 21926972)
Interacting Genes		7 interacting genes: APP CHEK2 HDAC4 MAD2L1 MAD2L2 REV1 WDR4	13 interacting genes: CLK1 FAAP20 FHL2 MAD2L2 POLD3 POLDIP2 POLH POLI POLK POLL REV3L TSC22D2 UBC
Entrez ID		5980	51455
HPRD ID		04145	16202
Ensembl ID		ENSG00000009413	ENSG00000135945
Uniprot IDs		O60673	Q49AI5 Q9UBZ9
PDB IDs		3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5O8K 6BC8 6BCD 6BI7 6EKM 6KEA 6WS0 6WS5	2EBW 2LSI 2LSK 2LSY 2N1G 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5 5VZM 6ASR 6AXD 6WS0 6WS5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Protein Lysine Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Error-prone Translesion Synthesis Cellular Response To Catecholamine Stimulus Response To Catecholamine Histone Deacetylase Activity Response To Stress Regulation Of Mitotic Cell Cycle Cardiac Muscle Hypertrophy Translesion Synthesis Regulation Of Ubiquitin-protein Transferase Activity Muscle Hypertrophy RNA Polymerase II-specific DNA-binding Transcription Factor Binding Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Postreplication Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Negative Regulation Of Mitotic Nuclear Division DNA Synthesis Involved In DNA Repair Negative Regulation Of RNA Metabolic Process Histone Deacetylase Complex Dendrite Development Epigenetic Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Glycolytic Process DNA Damage Response Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Response To Amyloid-beta Positive Regulation Of Cell Cycle Nucleus Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Carbohydrate Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion	Translesion Synthesis Postreplication Repair DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Error-prone Translesion Synthesis DNA-directed DNA Polymerase Activity DNA Polymerase Activity DNA Repair DNA Metabolic Process DNA Replication DNA Damage Response Zeta DNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process Nucleotidyltransferase Activity Macromolecule Biosynthetic Process Cellular Response To Stress Nucleic Acid Metabolic Process Error-free Translesion Synthesis Nucleotide-excision Repair, DNA Gap Filling Damaged DNA Binding Response To Stress Nucleobase-containing Compound Metabolic Process Site Of Double-strand Break Nucleoplasm Nucleus Somatic Diversification Of Immunoglobulins Double-strand Break Repair DNA-templated DNA Replication DNA Damage Response, Signal Transduction Resulting In Transcription Macromolecule Metabolic Process Transferase Activity Atrial Cardiac Muscle Cell Development Cellular Response To UV DNA Synthesis Involved In UV-damage Excision Repair Delta DNA Polymerase Complex Cellular Response To Light Stimulus Cellular Response To UV-C DNA Binding Vascular Associated Smooth Muscle Cell Proliferation
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