REV3L and MAD2L2

Number of citations of the paper that reports this interaction (PubMedID 11485998)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		REV3L	MAD2L2
Description		REV3 like, DNA directed polymerase zeta catalytic subunit	mitotic arrest deficient 2 like 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Zeta DNA Polymerase Complex Nuclear Lumen	Chromatin Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Spindle Cytoskeleton Zeta DNA Polymerase Complex Site Of Double-strand Break
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Transcription Corepressor Activity Protein Binding JUN Kinase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response Translesion Synthesis Error-prone Translesion Synthesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair Double-strand Break Repair DNA Damage Response Actin Filament Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Positive Regulation Of DNA-templated Transcription Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 23128233 28067908) Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 26414677) Psoriasis ( 25574825) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549) Ulcerative colitis ( 28067908)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		7 interacting genes: APP CHEK2 HDAC4 MAD2L1 MAD2L2 REV1 WDR4	47 interacting genes: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 CIMIP1 DEPDC5 ELK1 FAM217B FTO FZR1 GSC2 IKZF1 IKZF3 INCA1 KCTD9 KRT34 MAD2L1 MAD2L1BP MBD3L1 MYBPC2 PLAGL2 POLDIP2 PPM1B PRCC PRR5L PRRC2A RAB11FIP4 RBBP6 REL REV1 REV3L SFI1 SHLD1 TCF4 THAP6 TRIM27 TRIM54 TRIM7 YPEL3 YY1AP1 ZBED1 ZMYND12 ZNF511 ZNF558 ZNF655
Entrez ID		5980	10459
HPRD ID		04145	07246
Ensembl ID		ENSG00000009413	ENSG00000116670
Uniprot IDs		O60673	Q9UI95
PDB IDs		3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5O8K 6BC8 6BCD 6BI7 6EKM 6KEA 6WS0 6WS5	3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6K07 6K08 6KEA 6KTO 6M7A 6M7B 6NIF 6VE5 6WS0 6WS5 6WW9 6WWA 7L9P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Protein Lysine Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Error-prone Translesion Synthesis Cellular Response To Catecholamine Stimulus Response To Catecholamine Histone Deacetylase Activity Response To Stress Regulation Of Mitotic Cell Cycle Cardiac Muscle Hypertrophy Translesion Synthesis Regulation Of Ubiquitin-protein Transferase Activity Muscle Hypertrophy RNA Polymerase II-specific DNA-binding Transcription Factor Binding Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Postreplication Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Negative Regulation Of Mitotic Nuclear Division DNA Synthesis Involved In DNA Repair Negative Regulation Of RNA Metabolic Process Histone Deacetylase Complex Dendrite Development Epigenetic Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Glycolytic Process DNA Damage Response Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Response To Amyloid-beta Positive Regulation Of Cell Cycle Nucleus Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Carbohydrate Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion	Mitotic Checkpoint Complex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Metal Ion Binding Translesion Synthesis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Protein Binding Positive Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle DNA Binding DNA Biosynthetic Process Postreplication Repair Error-free Translesion Synthesis Positive Regulation Of Synapse Maturation DNA Synthesis Involved In DNA Repair Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Negative Regulation Of Type I Interferon Production Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Regulation Of Mitotic Cell Cycle Ubiquitin Ligase Activator Activity Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle DNA-binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Zinc Ion Binding Regulation Of Mitotic Sister Chromatid Separation Regulation Of Nuclear Division Negative Regulation Of Interferon-beta Production Positive Regulation Of Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition SUMO Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Metabolic Process Sequence-specific DNA Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?