REV3L and MAD2L2

Number of citations of the paper that reports this interaction (PMID 11485998)
59

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		REV3L	MAD2L2
Gene Name		REV3-like, polymerase (DNA directed), zeta, catalytic subunit	MAD2 mitotic arrest deficient-like 2 (yeast)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Zeta DNA Polymerase Complex	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Zeta DNA Polymerase Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Polymerase II Activating Transcription Factor Binding Protein Binding JUN Kinase Binding
	Biological Process	DNA-dependent DNA Replication DNA Repair Error-prone Translesion Synthesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Growth DNA Repair Double-strand Break Repair Transcription, DNA-templated Actin Filament Organization Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Cell Division Negative Regulation Of APC-Cdc20 Complex Activity Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Translesion synthesis by Pol zeta DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template	Translesion synthesis by Pol zeta DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		5 interactors: CHEK2 HDAC4 MAD2L1 MAD2L2 REV1	22 interactors: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 ELK1 IKZF1 KCTD9 MAD2L1 POLDIP2 PRCC PRRC2A RBBP6 REL REV1 REV3L SFI1 TCF4 TRIM27 TRIP13 YY1AP1
Entrez ID		5980	10459
HPRD ID		04145	07246
Ensembl ID		ENSG00000009413	ENSG00000116670
Uniprot IDs		O60673	Q9UI95
PDB IDs		3ABD 3ABE 3VU7 4EXT 4GK0 4GK5	3ABD 3ABE 3VU7 4EXT 4GK0 4GK5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of APC-Cdc20 Complex Activity Mitotic Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Nuclear Division Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Division Negative Regulation Of Cell Cycle Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Signal Transduction In Response To DNA Damage DNA Repair Negative Regulation Of Protein Ubiquitination Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Cell Cycle Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Double-strand Break Repair Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Cell Cycle Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Cell Cycle Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Process Extracellular Matrix Disassembly PMA-inducible Membrane Protein Ectodomain Proteolysis Mitotic Cell Cycle Error-prone Translesion Synthesis Response To Stress Regulation Of Meiosis Regulation Of Meiotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cellular Component Organization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Collagen Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Translesion Synthesis Cell Cycle Checkpoint Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cell Adhesion Mediated By Integrin Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Division Multicellular Organismal Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Synapse Maturation Negative Regulation Of Transferase Activity Membrane Protein Ectodomain Proteolysis Regulation Of Synapse Maturation Postreplication Repair Cellular Response To Stress Proteolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Death Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Immune System Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Membrane Protein Proteolysis Tissue Development Negative Regulation Of Catalytic Activity Spindle Assembly Checkpoint Positive Regulation Of Protein Metabolic Process Innate Immune Response
Tagcloud ?		adriamycin cgi cgis cox7a2l cpg damaging deal distinctly enrichment hct116 hnrpul1 island jag2 mildly pcna peroxidase phenomena repressed scenarios scfd2 stabilize stabilized stresses syvn1 tor1aip1 unchanged varies verified xpmc2h	arrested cdk1 configuration eliminated fertility flexible g2 g9a glp h3k27me3 h3k9me2 infertile involves mad2b methyltransferases normally pgc pgcs primordial repressive reprogramming rev7 specification specified stably suppressive switch upregulate waves
Tagcloud (Difference) ?		adriamycin cgi cgis cox7a2l cpg damaging deal distinctly enrichment hct116 hnrpul1 island jag2 mildly pcna peroxidase phenomena repressed scenarios scfd2 stabilize stabilized stresses syvn1 tor1aip1 unchanged varies verified xpmc2h	arrested cdk1 configuration eliminated fertility flexible g2 g9a glp h3k27me3 h3k9me2 infertile involves mad2b methyltransferases normally pgc pgcs primordial repressive reprogramming rev7 specification specified stably suppressive switch upregulate waves
Tagcloud (Intersection) ?