REV3L and WDR4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		REV3L	WDR4
Description		REV3 like, DNA directed polymerase zeta catalytic subunit	WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Zeta DNA Polymerase Complex Nuclear Lumen	Nucleus Nucleoplasm Chromosome Cytosol TRNA Methyltransferase Complex TRNA (m7G46) Methyltransferase Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding Enzyme Activator Activity TRNA Methyltransferase Activator Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response Translesion Synthesis Error-prone Translesion Synthesis	TRNA Modification DNA Damage Response TRNA Processing RNA (guanine-N7)-methylation TRNA Stabilization TRNA (guanine-N7)-methylation
Pathways		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI	tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 23128233 28067908) Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 26414677) Psoriasis ( 25574825) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549) Ulcerative colitis ( 28067908)	Blood and toenail selenium levels ( 25343990) Fasting plasma glucose ( 28270201)
Interacting Genes		7 interacting genes: APP CHEK2 HDAC4 MAD2L1 MAD2L2 REV1 WDR4	18 interacting genes: CADPS2 CAPZA2 CDC42BPB COPS5 FAM118A FEN1 HLA-DRA METTL1 PAX6 PTPN23 RABGGTB REV3L SF3B4 TERF1 TERF2 UBE3A ZMYND8 ZNF84
Entrez ID		5980	10785
HPRD ID		04145	09330
Ensembl ID		ENSG00000009413	ENSG00000160193
Uniprot IDs		O60673	P57081
PDB IDs		3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5O8K 6BC8 6BCD 6BI7 6EKM 6KEA 6WS0 6WS5	7U20 8CTH 8CTI 8D58 8D9K 8D9L 8EG0 8H0N
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Protein Lysine Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Error-prone Translesion Synthesis Cellular Response To Catecholamine Stimulus Response To Catecholamine Histone Deacetylase Activity Response To Stress Regulation Of Mitotic Cell Cycle Cardiac Muscle Hypertrophy Translesion Synthesis Regulation Of Ubiquitin-protein Transferase Activity Muscle Hypertrophy RNA Polymerase II-specific DNA-binding Transcription Factor Binding Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Postreplication Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Negative Regulation Of Mitotic Nuclear Division DNA Synthesis Involved In DNA Repair Negative Regulation Of RNA Metabolic Process Histone Deacetylase Complex Dendrite Development Epigenetic Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Glycolytic Process DNA Damage Response Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Response To Amyloid-beta Positive Regulation Of Cell Cycle Nucleus Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Carbohydrate Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion	Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Shelterin Complex Telomerase Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping DNA Biosynthetic Process Macromolecule Metabolic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Organization RNA-templated DNA Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Nucleic Acid Metabolic Process Nucleoplasm DNA Metabolic Process Chromosome, Telomeric Region Internal MRNA (guanine-N7-)-methyltransferase Activity TRNA (guanine(46)-N7)-methyltransferase Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Homophilic Cell Adhesion Organelle Localization Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Double-stranded DNA Exodeoxyribonuclease Activity Regulation Of Chromosome Organization Flap Endonuclease Activity DNA Recombination
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