WDR4 and CAPZA2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		WDR4	CAPZA2
Description		WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit	capping actin protein of muscle Z-line subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol TRNA Methyltransferase Complex TRNA (m7G46) Methyltransferase Complex	Extracellular Region Cytosol Brush Border F-actin Capping Protein Complex Actin Cytoskeleton Membrane Cortical Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Enzyme Activator Activity TRNA Methyltransferase Activator Activity	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	TRNA Modification DNA Damage Response TRNA Processing RNA (guanine-N7)-methylation TRNA Stabilization TRNA (guanine-N7)-methylation	Actin Cytoskeleton Organization Barbed-end Actin Filament Capping Actin Filament Capping Protein-containing Complex Assembly
Pathways		tRNA modification in the nucleus and cytosol	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Sensory processing of sound by inner hair cells of the cochlea Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Blood and toenail selenium levels ( 25343990) Fasting plasma glucose ( 28270201)	Heel bone mineral density x serum urate levels interaction ( 34046847) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878) Triglyceride levels ( 32154731 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: CADPS2 CAPZA2 CDC42BPB COPS5 FAM118A FEN1 HLA-DRA METTL1 PAX6 PTPN23 RABGGTB REV3L SF3B4 TERF1 TERF2 UBE3A ZMYND8 ZNF84	5 interacting genes: CAPZA3 HSPB2 PDE4B RBBP6 WDR4
Entrez ID		10785	830
HPRD ID		09330	11871
Ensembl ID		ENSG00000160193	ENSG00000198898
Uniprot IDs		P57081	A4D0V4 P47755
PDB IDs		7U20 8CTH 8CTI 8D58 8D9K 8D9L 8EG0 8H0N
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Shelterin Complex Telomerase Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping DNA Biosynthetic Process Macromolecule Metabolic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Organization RNA-templated DNA Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Nucleic Acid Metabolic Process Nucleoplasm DNA Metabolic Process Chromosome, Telomeric Region Internal MRNA (guanine-N7-)-methyltransferase Activity TRNA (guanine(46)-N7)-methyltransferase Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Homophilic Cell Adhesion Organelle Localization Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Double-stranded DNA Exodeoxyribonuclease Activity Regulation Of Chromosome Organization Flap Endonuclease Activity DNA Recombination	Somatic Muscle Development Protein Folding Cytosol Enzyme Activator Activity Neutrophil Homeostasis Negative Regulation Of Relaxation Of Muscle CAMP Catabolic Process Postsynaptic Density Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Actin Filament-based Process Regulation Of Relaxation Of Cardiac Muscle Memory T Cell Differentiation Regulation Of Cellular Component Size TSC1-TSC2 Complex ATPase Inhibitor Activity Negative Regulation Of Cell Size TRNA Methyltransferase Complex RNA (guanine-N7)-methylation TRNA (guanine-N7)-methylation TRNA Stabilization TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex F-actin Capping Protein Complex Cytoplasm Organization
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