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WDR4 and METTL1
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
HPRD
(in vivo, two hybrid)
WDR4
METTL1
Gene Name
WD repeat domain 4
methyltransferase like 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
TRNA Methyltransferase Complex
Molecular Function
Protein Binding
TRNA (guanine-N7-)-methyltransferase Activity
TRNA Binding
Protein Binding
TRNA (guanine-N7-)-methyltransferase Activity
Biological Process
TRNA Modification
TRNA Methylation
RNA (guanine-N7)-methylation
TRNA Modification
TRNA Methylation
RNA (guanine-N7)-methylation
Pathways
Drugs
Diseases
GWAS
Multiple sclerosis (
19525955
)
Protein-Protein Interactions
5 interactors:
FAM118A
METTL1
RABGGTB
TERF1
TERF2
3 interactors:
AKT1
RPS6KA1
WDR4
Entrez ID
10785
4234
HPRD ID
09330
06834
Ensembl ID
ENSG00000160193
ENSG00000037897
Uniprot IDs
P57081
Q9UBP6
PDB IDs
3CKK
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Telomeric Loop Formation
Age-dependent Telomere Shortening
Telomere Maintenance Via Telomere Shortening
Replicative Cell Aging
Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
Regulation Of Nuclear Cell Cycle DNA Replication
Regulation Of Telomere Maintenance
RNA-dependent DNA Replication
Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of DNA Replication
Cell Aging
Telomere Maintenance
Negative Regulation Of Chromosome Organization
Negative Regulation Of DNA Metabolic Process
Regulation Of DNA Replication
Regulation Of Chromosome Organization
RNA (guanine-N7)-methylation
Protection From Non-homologous End Joining At Telomere
Telomere Capping
DNA Replication
Negative Regulation Of Telomere Maintenance Via Telomerase
Protein Localization To Chromosome, Telomeric Region
Protein Geranylgeranylation
Aging
Negative Regulation Of Telomerase Activity
Positive Regulation Of Telomere Maintenance
Positive Regulation Of Organelle Organization
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Cell Cycle
Positive Regulation Of Microtubule Polymerization
Regulation Of Cell Cycle Process
Regulation Of Telomerase Activity
Protein Prenylation
Chromatin Modification
TRNA Methylation
Negative Regulation Of DNA Biosynthetic Process
Regulation Of Microtubule Polymerization
Protein Localization To Chromosome
Cellular Senescence
Chromatin Organization
7-methylguanosine RNA Capping
Mitotic Spindle Assembly Checkpoint
Spindle Assembly Checkpoint
Mitotic Spindle Checkpoint
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of Chromosome Segregation
Regulation Of DNA Biosynthetic Process
Spindle Checkpoint
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Cell Growth
Glycogen Cell Differentiation Involved In Embryonic Placenta Development
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Hepatic Stellate Cell Activation
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Growth
Neurotrophin Signaling Pathway
Negative Regulation Of Endopeptidase Activity
Regulation Of Translation
Negative Regulation Of Peptidase Activity
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Negative Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Cell Activation
Regulation Of Cell Growth
Negative Regulation Of Proteolysis
RNA (guanine-N7)-methylation
Response To UV-A
Negative Regulation Of Protein Processing
Regulation Of Endopeptidase Activity
Activation-induced Cell Death Of T Cells
Negative Regulation Of Hydrolase Activity
Regulation Of Protein Processing
Regulation Of Peptidase Activity
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Posttranscriptional Regulation Of Gene Expression
Immune Response-regulating Signaling Pathway
Regulation Of Cell Activation
Negative Regulation Of Fatty Acid Oxidation
Positive Regulation Of Glycogen Biosynthetic Process
Nitric Oxide Biosynthetic Process
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Size
Response To Growth Factor
Regulation Of Translation In Response To Stress
Regulation Of Growth
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Spongiotrophoblast Layer Development
T Cell Apoptotic Process
Regulation Of Fatty Acid Beta-oxidation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Nitric-oxide Synthase Activity
Regulation Of Proteolysis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
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