WDR4 and ZMYND8

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		WDR4	ZMYND8
Description		WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit	zinc finger MYND-type containing 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol TRNA Methyltransferase Complex TRNA (m7G46) Methyltransferase Complex	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Dendritic Spine Dendritic Shaft Site Of DNA Damage
	Molecular Function	Protein Binding Enzyme Activator Activity TRNA Methyltransferase Activator Activity	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding Histone H3K14ac Reader Activity Histone H3K4me1 Reader Activity DNA-binding Transcription Factor Binding
	Biological Process	TRNA Modification DNA Damage Response TRNA Processing RNA (guanine-N7)-methylation TRNA Stabilization TRNA (guanine-N7)-methylation	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Chromatin Organization Regulation Of DNA-templated Transcription Nervous System Development Negative Regulation Of Cell Migration Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Filopodium Assembly Positive Regulation Of Dendritic Spine Development Protein Localization To Chromatin Modulation Of Excitatory Postsynaptic Potential Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Dendritic Spine Maintenance
Pathways		tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Blood and toenail selenium levels ( 25343990) Fasting plasma glucose ( 28270201)	Bipolar disorder ( 34099189) Caffeine consumption from coffee ( 33287642) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Migraine ( 27182965) Parahippocampal gyrus volume ( 31530798) Platelet distribution width ( 32888494) Response to protease inhibitor treatment in hepatitis c (bilirubin toxicity) ( 24503447) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: CADPS2 CAPZA2 CDC42BPB COPS5 FAM118A FEN1 HLA-DRA METTL1 PAX6 PTPN23 RABGGTB REV3L SF3B4 TERF1 TERF2 UBE3A ZMYND8 ZNF84	17 interacting genes: ATN1 ATRX CSNK1E ERBB2 FHOD1 FMR1 FXR2 MEOX2 PBXIP1 PRKCB RERE SPOP SUMO2 USP7 WDR4 ZBTB7A ZFYVE9
Entrez ID		10785	23613
HPRD ID		09330	10166
Ensembl ID		ENSG00000160193	ENSG00000101040
Uniprot IDs		P57081	A0A087WVZ6 A6H8Y8 Q2HXV5 Q569J9 Q9ULU4
PDB IDs		7U20 8CTH 8CTI 8D58 8D9K 8D9L 8EG0 8H0N	4COS 5B73 5MQ4 5Y1Z 7CWH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Shelterin Complex Telomerase Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping DNA Biosynthetic Process Macromolecule Metabolic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Organization RNA-templated DNA Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Nucleic Acid Metabolic Process Nucleoplasm DNA Metabolic Process Chromosome, Telomeric Region Internal MRNA (guanine-N7-)-methyltransferase Activity TRNA (guanine(46)-N7)-methyltransferase Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Homophilic Cell Adhesion Organelle Localization Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Double-stranded DNA Exodeoxyribonuclease Activity Regulation Of Chromosome Organization Flap Endonuclease Activity DNA Recombination	Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Proteasomal Protein Catabolic Process DNA Damage Response Chromatin Organization DNA Repair Translation Regulator Activity Transcription Coactivator Activity PML Body Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Nuclear Androgen Receptor Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin Remodeling Presynaptic Cytosol Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Translation Negative Regulation Of Metabolic Process DNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Transport Of Viral Material Gene Expression Involved In Extracellular Matrix Organization
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