WDR4 and CDC42BPB

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		WDR4	CDC42BPB
Description		WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit	CDC42 binding protein kinase beta
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol TRNA Methyltransferase Complex TRNA (m7G46) Methyltransferase Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Lamellipodium Cell Leading Edge Actomyosin Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Enzyme Activator Activity TRNA Methyltransferase Activator Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	TRNA Modification DNA Damage Response TRNA Processing RNA (guanine-N7)-methylation TRNA Stabilization TRNA (guanine-N7)-methylation	Protein Phosphorylation Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Migration Actin Cytoskeleton Organization Actomyosin Structure Organization
Pathways		tRNA modification in the nucleus and cytosol	CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle
Drugs
Diseases
GWAS		Blood and toenail selenium levels ( 25343990) Fasting plasma glucose ( 28270201)	A body shape index ( 34021172) Body mass index ( 26426971) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		18 interacting genes: CADPS2 CAPZA2 CDC42BPB COPS5 FAM118A FEN1 HLA-DRA METTL1 PAX6 PTPN23 RABGGTB REV3L SF3B4 TERF1 TERF2 UBE3A ZMYND8 ZNF84	7 interacting genes: CDC42 MAP2K5 PPM1A PPP2CA PYGM RIPK1 WDR4
Entrez ID		10785	9578
HPRD ID		09330	08516
Ensembl ID		ENSG00000160193	ENSG00000198752
Uniprot IDs		P57081	H0YLY0 Q86XZ8 Q9Y5S2
PDB IDs		7U20 8CTH 8CTI 8D58 8D9K 8D9L 8EG0 8H0N	3QFV 3TKU 4UAK 4UAL 5OTE 5OTF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Shelterin Complex Telomerase Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping DNA Biosynthetic Process Macromolecule Metabolic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Organization RNA-templated DNA Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Nucleic Acid Metabolic Process Nucleoplasm DNA Metabolic Process Chromosome, Telomeric Region Internal MRNA (guanine-N7-)-methyltransferase Activity TRNA (guanine(46)-N7)-methyltransferase Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Homophilic Cell Adhesion Organelle Localization Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Double-stranded DNA Exodeoxyribonuclease Activity Regulation Of Chromosome Organization Flap Endonuclease Activity DNA Recombination	Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Hippo Signaling Cellular Response To Fluid Shear Stress Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intracellular Signal Transduction Regulation Of Hippo Signaling Tau Protein Binding Response To Fluid Shear Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apical Part Of Cell GBD Domain Binding Storage Vacuole Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine Kinase Activity Cellular Response To Growth Factor Stimulus Protein Dephosphorylation Response To Growth Factor Protein Serine/threonine Phosphatase Activity Regulation Of Canonical NF-kappaB Signal Transduction RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Interleukin-8 Production ERK5 Cascade Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex Protein Serine/threonine Kinase Activity Nucleotide Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Glycogen Phosphorylase Activity Positive Regulation Of Interleukin-6-mediated Signaling Pathway Death Domain Binding TRNA (guanine-N7)-methylation Apolipoprotein A-I Receptor Binding Intracellular Signal Transduction Neuropilin Signaling Pathway Regulation Of Cell Cycle Cytosol N-terminal Protein Myristoylation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Mitotic Cell Cycle Protein Kinase Activity
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