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BAX and NOL3
Number of citations of the paper that reports this interaction (PubMedID
15383280
)
0
Data Source:
HPRD
(in vivo)
BAX
NOL3
Description
BCL2 associated X, apoptosis regulator
nucleolar protein 3
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Permeability Transition Pore Complex
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Mitochondrial Membrane
Pore Complex
Extracellular Exosome
Cell Periphery
Bcl-2 Family Protein Complex
BAX Complex
BAK Complex
Nucleus
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Membrane
Sarcoplasm
Sarcoplasmic Reticulum
Molecular Function
Protein Binding
Lipid Binding
Channel Activity
Hsp70 Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein-folding Chaperone Binding
BH3 Domain Binding
RNA Binding
Signaling Receptor Binding
Death Receptor Binding
Calcium Ion Binding
Protein Binding
Death Effector Domain Binding
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Caspase Binding
Biological Process
Ovarian Follicle Development
Neuron Migration
Leukocyte Homeostasis
T Cell Homeostatic Proliferation
B Cell Homeostasis
B Cell Apoptotic Process
Kidney Development
Release Of Cytochrome C From Mitochondria
Blood Vessel Remodeling
Myeloid Cell Homeostasis
B Cell Negative Selection
B Cell Homeostatic Proliferation
Positive Regulation Of B Cell Apoptotic Process
Glycosphingolipid Metabolic Process
Regulation Of Nitrogen Utilization
Apoptotic Process
DNA Damage Response
Mitochondrion Organization
Germ Cell Development
Spermatogenesis
Nervous System Development
Sex Differentiation
Mitochondrial Fusion
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Apoptotic Mitochondrial Changes
Fertilization
Response To Wounding
Response To Toxic Substance
Response To Salt Stress
Post-embryonic Development
Response To Ionizing Radiation
Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
Response To Gamma Radiation
Positive Regulation Of Calcium Ion Transport Into Cytosol
Negative Regulation Of Mitochondrial Membrane Potential
Hypothalamus Development
Cerebral Cortex Development
Positive Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Protein Binding
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Release Of Matrix Enzymes From Mitochondria
Cellular Response To Stress
Regulation Of Mammary Gland Epithelial Cell Proliferation
Cellular Response To Unfolded Protein
Cellular Response To UV
Limb Morphogenesis
Ectopic Germ Cell Programmed Cell Death
Odontogenesis Of Dentin-containing Tooth
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Mitochondrial Fragmentation Involved In Apoptotic Process
Development Of Secondary Sexual Characteristics
Retinal Cell Programmed Cell Death
Positive Regulation Of Developmental Pigmentation
Negative Regulation Of Fibroblast Proliferation
Spermatid Differentiation
Post-embryonic Camera-type Eye Morphogenesis
Response To Axon Injury
Homeostasis Of Number Of Cells
Homeostasis Of Number Of Cells Within A Tissue
Epithelial Cell Proliferation
Positive Regulation Of Developmental Process
Protein Insertion Into Mitochondrial Membrane
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Neuron Apoptotic Process
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Regulation Of Mitochondrial Membrane Potential
Sertoli Cell Proliferation
Retina Development In Camera-type Eye
Apoptotic Process Involved In Mammary Gland Involution
Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Vagina Development
Calcium Ion Transport Into Cytosol
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Thymocyte Apoptotic Process
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Motor Neuron Apoptotic Process
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Supramolecular Fiber Organization
Cellular Response To Virus
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Apoptotic Process Involved In Blood Vessel Morphogenesis
Apoptotic Process Involved In Embryonic Digit Morphogenesis
Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death
Positive Regulation Of Apoptotic DNA Fragmentation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Epithelial Cell Apoptotic Process
Positive Regulation Of Epithelial Cell Apoptotic Process
B Cell Receptor Apoptotic Signaling Pathway
Positive Regulation Of Reproductive Process
Positive Regulation Of Motor Neuron Apoptotic Process
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Response To Hypoxia
Blood Vessel Remodeling
Response To Ischemia
MRNA Splice Site Recognition
MRNA Processing
Apoptotic Process
RNA Splicing
Negative Regulation Of Signal Transduction
Regulation Of Gene Expression
Cardiac Muscle Cell Apoptotic Process
Negative Regulation Of Striated Muscle Cell Apoptotic Process
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Muscle Atrophy
Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Response To Injury Involved In Regulation Of Muscle Adaptation
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Protein Complex Oligomerization
Negative Regulation Of Programmed Necrotic Cell Death
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Intrinsic Apoptotic Signaling Pathway
Regulation Of Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Release of apoptotic factors from the mitochondria
Activation, translocation and oligomerization of BAX
Pyroptosis
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Transcriptional regulation by RUNX2
NTRK3 as a dependence receptor
Drugs
TAK-901
Diseases
Colorectal cancer
GWAS
Asthma (
27611488
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte count (
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Plateletcrit (
32888494
)
Sum eosinophil basophil counts (
27863252
)
White blood cell count (
32888494
)
Interacting Genes
30 interacting genes:
ANP32B
BAK1
BBC3
BCL2
BCL2A1
BCL2L1
BCL2L10
BID
ERN1
FBXL20
HSF2BP
KCNA3
LEF1
MAP2K1
MCL1
MOAP1
NOL3
PARK7
PMAIP1
PPP1CA
SFN
SH3GLB1
SLC25A4
TRIM17
UHRF2
USP12
VDAC1
YWHAB
YWHAQ
ZBTB24
17 interacting genes:
BAX
CASP2
CASP8
CSNK2A1
ETNK2
FADD
NIF3L1
POT1
SIRPA
SRSF9
TERF1
TERF2IP
TFPT
TINF2
TRAF6
UBQLN2
VASP
Entrez ID
581
8996
HPRD ID
02498
05572
Ensembl ID
ENSG00000087088
ENSG00000140939
Uniprot IDs
I6LPK7
Q07812
Q5ZPJ0
Q5ZPJ1
O60936
Q5TZN6
PDB IDs
1F16
2G5B
2K7W
2LR1
3PK1
3PL7
4BD2
4BD6
4BD7
4BD8
4BDU
4S0O
4S0P
4UF2
4ZIE
4ZIF
4ZIG
4ZIH
4ZII
5W5X
5W5Z
5W60
5W61
6EB6
6L8V
6L95
6TRR
6XY6
7ADT
8G1T
8SPE
8SPF
8SPZ
8SRX
8SRY
8SVK
4UZ0
Enriched GO Terms of Interacting Partners
?
Release Of Cytochrome C From Mitochondria
Apoptotic Mitochondrial Changes
Mitochondrion Organization
Intrinsic Apoptotic Signaling Pathway
Mitochondrial Outer Membrane
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Apoptotic Process
Regulation Of Apoptotic Signaling Pathway
Bcl-2 Family Protein Complex
Regulation Of Programmed Cell Death
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Programmed Cell Death
Cell Death
DNA Damage Response
Mitochondrial Membrane Organization
Regulation Of Mitochondrion Organization
Extrinsic Apoptotic Signaling Pathway
Regulation Of Membrane Permeability
Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Process
Channel Activity
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Response To Stress
Cellular Response To Stress
Mitochondrion
Regulation Of Mitochondrial Membrane Potential
Intracellular Signal Transduction
Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Cellular Response To Stress
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Membrane Permeability
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
BH3 Domain Binding
Organelle Organization
Positive Regulation Of Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Autophagy
Mitochondrial Membrane
Shelterin Complex
Nuclear Telomere Cap Complex
Telomere Capping
Execution Phase Of Apoptosis
Positive Regulation Of Telomere Maintenance
Telomeric DNA Binding
Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Chromosome Organization
Regulation Of Telomere Maintenance
G-rich Strand Telomeric DNA Binding
Telomere Organization
Negative Regulation Of DNA Metabolic Process
Positive Regulation Of DNA Metabolic Process
Regulation Of DNA Metabolic Process
Positive Regulation Of Organelle Organization
Positive Regulation Of Cellular Component Organization
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Chromosome Organization
Telomere Maintenance Via Telomerase
RNA-templated DNA Biosynthetic Process
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of DNA Biosynthetic Process
Tumor Necrosis Factor Receptor Binding
Regulation Of Chromosome Organization
Positive Regulation Of Metabolic Process
Death Effector Domain Binding
Telomere Assembly
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Cellular Component Organization
Regulation Of Telomere Maintenance Via Telomerase
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Organelle Organization
Regulation Of Cellular Response To Stress
Ripoptosome
CD95 Death-inducing Signaling Complex
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Organelle Organization
Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Signaling Pathway
Death-inducing Signaling Complex
Regulation Of Telomere Maintenance Via Telomere Lengthening
Chromosome Organization
Chromosome, Telomeric Region
Positive Regulation Of Myeloid Leukocyte Differentiation
TRAIL-activated Apoptotic Signaling Pathway
Telomeric D-loop Disassembly
Identical Protein Binding
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