BAX and BBC3

Number of citations of the paper that reports this interaction (PubMedID 34587475)
42

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		BAX	BBC3
Description		BCL2 associated X, apoptosis regulator	BCL2 binding component 3
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Pore Complex Extracellular Exosome Cell Periphery Bcl-2 Family Protein Complex BAX Complex BAK Complex	Mitochondrion Mitochondrial Outer Membrane Lysosome Cytosol
	Molecular Function	Protein Binding Lipid Binding Channel Activity Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein-folding Chaperone Binding BH3 Domain Binding	Protein Binding ATPase Binding
	Biological Process	Ovarian Follicle Development Neuron Migration Leukocyte Homeostasis T Cell Homeostatic Proliferation B Cell Homeostasis B Cell Apoptotic Process Kidney Development Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection B Cell Homeostatic Proliferation Positive Regulation Of B Cell Apoptotic Process Glycosphingolipid Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process DNA Damage Response Mitochondrion Organization Germ Cell Development Spermatogenesis Nervous System Development Sex Differentiation Mitochondrial Fusion Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Fertilization Response To Wounding Response To Toxic Substance Response To Salt Stress Post-embryonic Development Response To Ionizing Radiation Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Mitochondrial Membrane Potential Hypothalamus Development Cerebral Cortex Development Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Release Of Matrix Enzymes From Mitochondria Cellular Response To Stress Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Unfolded Protein Cellular Response To UV Limb Morphogenesis Ectopic Germ Cell Programmed Cell Death Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Development Of Secondary Sexual Characteristics Retinal Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Negative Regulation Of Fibroblast Proliferation Spermatid Differentiation Post-embryonic Camera-type Eye Morphogenesis Response To Axon Injury Homeostasis Of Number Of Cells Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Positive Regulation Of Developmental Process Protein Insertion Into Mitochondrial Membrane Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Establishment Of Localization In Cell Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Sertoli Cell Proliferation Retina Development In Camera-type Eye Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Vagina Development Calcium Ion Transport Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Supramolecular Fiber Organization Cellular Response To Virus Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Blood Vessel Morphogenesis Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Positive Regulation Of Apoptotic DNA Fragmentation Regulation Of Intracellular Signal Transduction Positive Regulation Of IRE1-mediated Unfolded Protein Response Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process B Cell Receptor Apoptotic Signaling Pathway Positive Regulation Of Reproductive Process Positive Regulation Of Motor Neuron Apoptotic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Release Of Cytochrome C From Mitochondria Apoptotic Process DNA Damage Response Determination Of Adult Lifespan Positive Regulation Of Protein-containing Complex Assembly Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Lymphocyte Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Release of apoptotic factors from the mitochondria Activation, translocation and oligomerization of BAX Pyroptosis TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Transcriptional regulation by RUNX2 NTRK3 as a dependence receptor	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FOXO-mediated transcription of cell death genes
Drugs		TAK-901
Diseases		Colorectal cancer
GWAS		Asthma ( 27611488) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Monocyte count ( 27863252) White blood cell count ( 32888494)
Interacting Genes		30 interacting genes: ANP32B BAK1 BBC3 BCL2 BCL2A1 BCL2L1 BCL2L10 BID ERN1 FBXL20 HSF2BP KCNA3 LEF1 MAP2K1 MCL1 MOAP1 NOL3 PARK7 PMAIP1 PPP1CA SFN SH3GLB1 SLC25A4 TRIM17 UHRF2 USP12 VDAC1 YWHAB YWHAQ ZBTB24	15 interacting genes: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 FBXL20 FHL5 HGS HSD17B13 MCL1 MYPOP NDUFAB1 UBASH3B WDR5 ZNF438
Entrez ID		581	27113
HPRD ID		02498	16165
Ensembl ID		ENSG00000087088	ENSG00000105327
Uniprot IDs		I6LPK7 Q07812 Q5ZPJ0 Q5ZPJ1	Q96PG8 Q9BXH1
PDB IDs		1F16 2G5B 2K7W 2LR1 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU 4S0O 4S0P 4UF2 4ZIE 4ZIF 4ZIG 4ZIH 4ZII 5W5X 5W5Z 5W60 5W61 6EB6 6L8V 6L95 6TRR 6XY6 7ADT 8G1T 8SPE 8SPF 8SPZ 8SRX 8SRY 8SVK	2M04 4BPI 4BPJ 4BPK 4HNJ 5UUL 6QFM 6QG8 6TQP 7DVD 7P0S 7P9W 7QTX
Enriched GO Terms of Interacting Partners?		Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Bcl-2 Family Protein Complex Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Programmed Cell Death Cell Death DNA Damage Response Mitochondrial Membrane Organization Regulation Of Mitochondrion Organization Extrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Channel Activity Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Positive Regulation Of Release Of Cytochrome C From Mitochondria Response To Stress Cellular Response To Stress Mitochondrion Regulation Of Mitochondrial Membrane Potential Intracellular Signal Transduction Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Membrane Permeability Positive Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Organelle Organization Positive Regulation Of Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Autophagy Mitochondrial Membrane	Release Of Cytochrome C From Mitochondria Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity BH3 Domain Binding Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Mitochondrion Organization Apoptotic Signaling Pathway Mitochondrial Membrane Mitochondrial Fusion Negative Regulation Of Anoikis Programmed Cell Death Involved In Cell Development Regulation Of Anoikis Regulation Of Nitrogen Utilization Retinal Cell Programmed Cell Death Dendritic Cell Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Ovarian Follicle Development Leukocyte Apoptotic Process Sertoli Cell Proliferation Response To Gamma Radiation Regulation Of Mitochondrial Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Developmental Pigmentation Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential DNA Damage Response Negative Regulation Of Apoptotic Signaling Pathway B Cell Apoptotic Process Calcium Ion Transport Into Cytosol Negative Regulation Of Apoptotic Process Regulation Of Developmental Pigmentation Pore Complex Regulation Of Neuron Apoptotic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Motor Neuron Apoptotic Process Regulation Of Motor Neuron Apoptotic Process Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Death
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