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BAX and BAK1
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(affinity chromatography technology, genetic interference, affinity chromatography technology)
HPRD
(in vivo)
BAX
BAK1
Description
BCL2 associated X, apoptosis regulator
BCL2 antagonist/killer 1
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Permeability Transition Pore Complex
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Mitochondrial Membrane
Pore Complex
Extracellular Exosome
Cell Periphery
Bcl-2 Family Protein Complex
BAX Complex
BAK Complex
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Cytosol
Membrane
Mitochondrial Membrane
Pore Complex
Bcl-2 Family Protein Complex
BAK Complex
Molecular Function
Protein Binding
Lipid Binding
Channel Activity
Hsp70 Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein-folding Chaperone Binding
BH3 Domain Binding
Protein Binding
Channel Activity
Porin Activity
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Transmembrane Transporter Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Protein-folding Chaperone Binding
BH Domain Binding
Biological Process
Ovarian Follicle Development
Neuron Migration
Leukocyte Homeostasis
T Cell Homeostatic Proliferation
B Cell Homeostasis
B Cell Apoptotic Process
Kidney Development
Release Of Cytochrome C From Mitochondria
Blood Vessel Remodeling
Myeloid Cell Homeostasis
B Cell Negative Selection
B Cell Homeostatic Proliferation
Positive Regulation Of B Cell Apoptotic Process
Glycosphingolipid Metabolic Process
Regulation Of Nitrogen Utilization
Apoptotic Process
DNA Damage Response
Mitochondrion Organization
Germ Cell Development
Spermatogenesis
Nervous System Development
Sex Differentiation
Mitochondrial Fusion
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Apoptotic Mitochondrial Changes
Fertilization
Response To Wounding
Response To Toxic Substance
Response To Salt Stress
Post-embryonic Development
Response To Ionizing Radiation
Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
Response To Gamma Radiation
Positive Regulation Of Calcium Ion Transport Into Cytosol
Negative Regulation Of Mitochondrial Membrane Potential
Hypothalamus Development
Cerebral Cortex Development
Positive Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Protein Binding
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Release Of Matrix Enzymes From Mitochondria
Cellular Response To Stress
Regulation Of Mammary Gland Epithelial Cell Proliferation
Cellular Response To Unfolded Protein
Cellular Response To UV
Limb Morphogenesis
Ectopic Germ Cell Programmed Cell Death
Odontogenesis Of Dentin-containing Tooth
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Mitochondrial Fragmentation Involved In Apoptotic Process
Development Of Secondary Sexual Characteristics
Retinal Cell Programmed Cell Death
Positive Regulation Of Developmental Pigmentation
Negative Regulation Of Fibroblast Proliferation
Spermatid Differentiation
Post-embryonic Camera-type Eye Morphogenesis
Response To Axon Injury
Homeostasis Of Number Of Cells
Homeostasis Of Number Of Cells Within A Tissue
Epithelial Cell Proliferation
Positive Regulation Of Developmental Process
Protein Insertion Into Mitochondrial Membrane
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Neuron Apoptotic Process
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Regulation Of Mitochondrial Membrane Potential
Sertoli Cell Proliferation
Retina Development In Camera-type Eye
Apoptotic Process Involved In Mammary Gland Involution
Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Vagina Development
Calcium Ion Transport Into Cytosol
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Thymocyte Apoptotic Process
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Motor Neuron Apoptotic Process
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Supramolecular Fiber Organization
Cellular Response To Virus
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Apoptotic Process Involved In Blood Vessel Morphogenesis
Apoptotic Process Involved In Embryonic Digit Morphogenesis
Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death
Positive Regulation Of Apoptotic DNA Fragmentation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Epithelial Cell Apoptotic Process
Positive Regulation Of Epithelial Cell Apoptotic Process
B Cell Receptor Apoptotic Signaling Pathway
Positive Regulation Of Reproductive Process
Positive Regulation Of Motor Neuron Apoptotic Process
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Leukocyte Homeostasis
B Cell Homeostasis
B Cell Apoptotic Process
Release Of Cytochrome C From Mitochondria
Blood Vessel Remodeling
Myeloid Cell Homeostasis
B Cell Negative Selection
Apoptotic Process
Mitochondrial Fusion
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Xenobiotic Stimulus
Response To Fungus
Response To Mycotoxin
Response To UV-C
Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
Response To Gamma Radiation
Positive Regulation Of Calcium Ion Transport Into Cytosol
Negative Regulation Of Gene Expression
Endocrine Pancreas Development
Animal Organ Regeneration
Positive Regulation Of Protein-containing Complex Assembly
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Monoatomic Ion Transmembrane Transport
Cellular Response To Unfolded Protein
Cellular Response To UV
Limb Morphogenesis
Response To Hydrogen Peroxide
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Fibroblast Apoptotic Process
Response To Ethanol
Positive Regulation Of Proteolysis
Regulation Of Mitochondrial Membrane Permeability
Post-embryonic Camera-type Eye Morphogenesis
Homeostasis Of Number Of Cells
Epithelial Cell Proliferation
Regulation Of Transport
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Regulation Of Mitochondrial Membrane Potential
Vagina Development
Calcium Ion Transport Into Cytosol
Regulation Of Biological Quality
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Thymocyte Apoptotic Process
Cellular Response To Mechanical Stimulus
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Apoptotic Process Involved In Blood Vessel Morphogenesis
Regulation Of Intracellular Signal Transduction
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of Apoptotic Signaling Pathway
Pathways
Release of apoptotic factors from the mitochondria
Activation, translocation and oligomerization of BAX
Pyroptosis
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Transcriptional regulation by RUNX2
NTRK3 as a dependence receptor
Activation and oligomerization of BAK protein
Release of apoptotic factors from the mitochondria
Pyroptosis
Drugs
TAK-901
Diseases
Colorectal cancer
GWAS
Asthma (
27611488
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte count (
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Plateletcrit (
32888494
)
Sum eosinophil basophil counts (
27863252
)
White blood cell count (
32888494
)
Autism spectrum disorder or schizophrenia (
28540026
)
B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) (
28112199
)
Body mass index (
26426971
)
Chronic lymphocytic leukemia (
24292274
28165464
23770605
22700719
)
Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) (
30940143
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
27841878
)
Eosinophil count (
32888494
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Hematological parameters (
19820697
)
Lung cancer (
28604730
)
Multiple sclerosis and systolic blood pressure (pleiotropy) (
26920376
)
Neutrophil percentage of granulocytes (
27863252
)
Obesity-related traits (
23251661
)
Platelet count (
29066854
27863252
29403010
32888494
33545615
28031487
20139978
26805783
25705162
24026423
22139419
22423221
23263863
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Schizophrenia (
30285260
)
Spleen volume (
34128465
)
Sum eosinophil basophil counts (
27863252
)
Testicular germ cell tumor (
23666239
23666240
28604732
28604728
19483681
)
Interacting Genes
30 interacting genes:
ANP32B
BAK1
BBC3
BCL2
BCL2A1
BCL2L1
BCL2L10
BID
ERN1
FBXL20
HSF2BP
KCNA3
LEF1
MAP2K1
MCL1
MOAP1
NOL3
PARK7
PMAIP1
PPP1CA
SFN
SH3GLB1
SLC25A4
TRIM17
UHRF2
USP12
VDAC1
YWHAB
YWHAQ
ZBTB24
20 interacting genes:
ARHGDIA
BAX
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BID
DBN1
ERN1
HERC1
HSD17B4
HSPD1
MCL1
MFN1
NFKBIB
TP53
UBE3A
VDAC1
VDAC2
Entrez ID
581
578
HPRD ID
02498
02744
Ensembl ID
ENSG00000087088
ENSG00000030110
Uniprot IDs
I6LPK7
Q07812
Q5ZPJ0
Q5ZPJ1
A0A0S2Z391
Q16611
PDB IDs
1F16
2G5B
2K7W
2LR1
3PK1
3PL7
4BD2
4BD6
4BD7
4BD8
4BDU
4S0O
4S0P
4UF2
4ZIE
4ZIF
4ZIG
4ZIH
4ZII
5W5X
5W5Z
5W60
5W61
6EB6
6L8V
6L95
6TRR
6XY6
7ADT
8G1T
8SPE
8SPF
8SPZ
8SRX
8SRY
8SVK
1BXL
2IMS
2IMT
2JBY
2JCN
2LP8
2M5B
2XPX
2YV6
3I1H
3QBR
4D2L
4U2U
4U2V
4UF1
5AJK
5FMI
5FMK
5VWV
5VWW
5VWX
5VWY
5VWZ
5VX0
5VX1
6ODH
6UXM
6UXN
6UXO
6UXP
6UXQ
6UXR
7K02
7LK4
7M5A
7M5B
7OFM
7OFO
8CZF
8CZG
8CZH
8GSV
8IGC
8IVB
8SRX
8SRY
8UKY
8Y1Y
8Y1Z
Enriched GO Terms of Interacting Partners
?
Release Of Cytochrome C From Mitochondria
Apoptotic Mitochondrial Changes
Mitochondrion Organization
Intrinsic Apoptotic Signaling Pathway
Mitochondrial Outer Membrane
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Apoptotic Process
Regulation Of Apoptotic Signaling Pathway
Bcl-2 Family Protein Complex
Regulation Of Programmed Cell Death
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Programmed Cell Death
Cell Death
DNA Damage Response
Mitochondrial Membrane Organization
Regulation Of Mitochondrion Organization
Extrinsic Apoptotic Signaling Pathway
Regulation Of Membrane Permeability
Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Process
Channel Activity
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Response To Stress
Cellular Response To Stress
Mitochondrion
Regulation Of Mitochondrial Membrane Potential
Intracellular Signal Transduction
Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Cellular Response To Stress
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Membrane Permeability
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
BH3 Domain Binding
Organelle Organization
Positive Regulation Of Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Autophagy
Mitochondrial Membrane
Apoptotic Mitochondrial Changes
Release Of Cytochrome C From Mitochondria
Mitochondrion Organization
Mitochondrial Outer Membrane
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Channel Activity
Bcl-2 Family Protein Complex
Intrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
BH3 Domain Binding
Negative Regulation Of Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Programmed Cell Death
Regulation Of Membrane Permeability
Pore Complex
Apoptotic Process
Mitochondrial Membrane
Programmed Cell Death
Cell Death
Mitochondrial Membrane Organization
Mitochondrion
Mitochondrial Fusion
Regulation Of Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Regulation Of Mitochondrial Membrane Potential
Regulation Of Programmed Cell Death
Positive Regulation Of Mitochondrial Membrane Permeability
Cellular Response To Stress
Positive Regulation Of Membrane Permeability
Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Regulation Of Intrinsic Apoptotic Signaling Pathway
DNA Damage Response
Negative Regulation Of Autophagy
Intracellular Signal Transduction
Neuron Apoptotic Process
Regulation Of Autophagy
Regulation Of Release Of Cytochrome C From Mitochondria
Transmembrane Transport
Epithelial Cell Apoptotic Process
Ovarian Follicle Development
Mononuclear Cell Proliferation
Leukocyte Apoptotic Process
Response To Gamma Radiation
Leukocyte Proliferation
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
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