REST and SUB1

Number of citations of the paper that reports this interaction (PubMedID 20080105)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		REST	SUB1
Description		RE1 silencing transcription factor	SUB1 regulator of transcription
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Hypoxia Hematopoietic Progenitor Cell Differentiation Response To Ischemia Chromatin Remodeling Regulation Of DNA-templated Transcription Response To Stress Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Aldosterone Biosynthetic Process Cellular Response To Stress Somatic Stem Cell Population Maintenance Positive Regulation Of Programmed Cell Death Host-mediated Suppression Of Viral Transcription Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Nervous System Process Neuromuscular Process Controlling Balance Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Auditory Receptor Cell Stereocilium Organization Cardiac Muscle Cell Myoblast Differentiation Cellular Response To Electrical Stimulus Cellular Response To Glucocorticoid Stimulus Neuronal Stem Cell Population Maintenance Modification Of Synaptic Structure Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of MiRNA Transcription Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Amniotic Stem Cell Differentiation	RNA Polymerase II Promoter Clearance Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		HDACs deacetylate histones Regulation of PTEN gene transcription NGF-stimulated transcription Potential therapeutics for SARS Regulation of NPAS4 gene transcription
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Age-related macular degeneration ( 21909106) Appendicular lean mass ( 33097823) Coronary artery disease ( 26343387 33020668 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 31562340 25429064) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Migraine ( 27322543) Myocardial infarction ( 33532862) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 29403010) Plateletcrit ( 32888494) Response to bleomycin (chromatid breaks) ( 21106707) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) White blood cell count ( 32888494)	Metabolite levels ( 23823483) PR interval ( 32439900)
Interacting Genes		11 interacting genes: AURKA CDYL CELSR3 GTF2B HTT MAPK1 PLK1 RCOR1 SIN3B SUB1 TBP	24 interacting genes: ADAP1 APP CBX5 CEBPA CSNK2A1 CSTF2 EP300 GTF2A1L HNF4A HSF1 OTUD5 PCNA POLR2A POLR2B POU2AF1 PSIP1 RCOR1 REST RNF10 SDCBP SP1 TAF1 TBP TP53
Entrez ID		5978	10923
HPRD ID		08990	02737
Ensembl ID		ENSG00000084093	ENSG00000113387
Uniprot IDs		A0A1W2PQA1 Q13127	P53999 Q6IBA2
PDB IDs		2CZY 6DU2 6DU3	1PCF 2C62 2PHE 4USG 6YCS 7E4W
Enriched GO Terms of Interacting Partners?		Germinal Vesicle Centriole Pronucleus Centrosome Separation Microtubule Organizing Center Organization RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Protein Stability Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule-based Process Protein Localization To Centrosome Spindle Midzone Spindle Organization Nucleoplasm Microtubule Cytoskeleton Organization Kinetochore Transcription Factor TFIID Complex Positive Regulation Of Cilium Assembly Sister Chromatid Cohesion RNA Polymerase II General Transcription Initiation Factor Activity Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Positive Regulation Of Organelle Organization Establishment Of Mitotic Spindle Orientation Peptidyl-serine Phosphorylation Spindle Microtubule Mitotic Spindle Pole Transcription Corepressor Activity RNA Polymerase II Preinitiation Complex Assembly Transcription Initiation At RNA Polymerase II Promoter Protein Localization To Cytoskeleton Centrosome Cycle Spindle Transcriptional Start Site Selection At RNA Polymerase II Promoter Establishment Of Spindle Localization Identical Protein Binding Regulation Of Organelle Assembly Microtubule Cytoskeleton G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Peptidyl-lysine Crotonylation Cell Cycle G2/M Phase Transition Transcription Preinitiation Complex Assembly Membraneless Organelle Assembly Protein Destabilization Spindle Localization Regulation Of Organelle Organization Centrosome Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation RNA Polymerase II Core Complex Assembly Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Repressor Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process STAT Family Protein Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Chromatin Organization Rhythmic Process Euchromatin MRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Xenobiotic Stimulus RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Cellular Response To Radiation DNA-binding Transcription Factor Binding
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