REST and CDYL

Number of citations of the paper that reports this interaction (PMID 19061646)
30

Data Source:
BioGRID (pull down)

		REST	CDYL
Gene Name		RE1-silencing transcription factor	chromodomain protein, Y-like
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Transcriptional Repressor Complex	Nucleus Nucleoplasm
	Molecular Function	Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Outward Rectifier Potassium Channel Activity Transcription Regulatory Region DNA Binding Metal Ion Binding	Transcription Corepressor Activity Histone Acetyltransferase Activity Protein Binding Methylated Histone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Hematopoietic Progenitor Cell Differentiation Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Aldosterone Biosynthetic Process Cellular Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation By Host Of Viral Transcription Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Cardiac Muscle Cell Myoblast Differentiation Histone H4 Deacetylation Cellular Response To Electrical Stimulus Cellular Response To Glucocorticoid Stimulus Potassium Ion Transmembrane Transport Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Amniotic Stem Cell Differentiation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Spermatogenesis Histone Acetylation Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21909106) Bleomycin sensitivity ( 21106707)	Chronic obstructive pulmonary disease ( 21685187)
Protein-Protein Interactions		7 interactors: CDYL GTF2B HTT RCOR1 SIN3B SUB1 TBP	5 interactors: HDAC1 HDAC2 HIST3H3 HTRA1 REST
Entrez ID		5978	9425
HPRD ID		08990	04803
Ensembl ID		ENSG00000084093	ENSG00000153046
Uniprot IDs		Q13127	Q9Y232
PDB IDs		2CZY	2DNT 2GTR
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription Elongation From RNA Polymerase II Promoter Histone Modification Histone Deacetylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Deacetylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Elongation Regulation Of RNA Metabolic Process Neural Plate Formation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Spermatogenesis Male Gamete Generation Regulation Of Metabolic Process Viral Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Gamete Generation Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Regulation Of Protein Phosphatase Type 2A Activity Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Lactate Biosynthetic Process Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Paraxial Mesoderm Formation Negative Regulation Of Cellular Metabolic Process	Histone H4 Deacetylation Histone Deacetylation Protein Deacetylation Odontogenesis Of Dentin-containing Tooth Fungiform Papilla Formation Fungiform Papilla Morphogenesis Positive Regulation Of Receptor Biosynthetic Process Odontogenesis Fungiform Papilla Development Negative Regulation By Host Of Viral Transcription Eyelid Development In Camera-type Eye Hair Follicle Placode Formation Tongue Morphogenesis Regulation Of Receptor Biosynthetic Process Negative Regulation Of Viral Transcription Histone H3 Deacetylation Chromosome Organization Interaction With Symbiont Tongue Development Histone H3-K9 Modification Negative Regulation Of Signaling Histone Modification Regulation Of Cell Proliferation Embryonic Digit Morphogenesis ATP-dependent Chromatin Remodeling Regulation Of Viral Transcription Circadian Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Viral Process Hair Follicle Development Hair Cycle Process Chromatin Modification Hair Cycle Negative Regulation Of Amniotic Stem Cell Differentiation Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Chromatin Organization Cardiocyte Differentiation Epidermal Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Regulation Of Viral Process Embryonic Limb Morphogenesis Circadian Rhythm Limb Morphogenesis Chromatin Remodeling Maintenance Of Chromatin Silencing Negative Regulation Of Neuron Differentiation Limb Development Organ Morphogenesis
Tagcloud ?		areas bph cellular coefficient composition depends dpv equation glands granular histological mathematical mm2 morphometric mu2 ncr pearson prostate prostatic random secreto ser stroma sum transurethral us vascularization vessels volume	arborization bdnf chromodomain circuits complexity connections coordinately corepressor dendrite dendritic establishment ezh2 h3k27 interdependent knock knocking mechanistically morphogenesis neurodevelopment neurotrophic polycomb prc2 recruits repressive restrict shed throughput unleash unraveling
Tagcloud (Difference) ?		areas bph cellular coefficient composition depends dpv equation glands granular histological mathematical mm2 morphometric mu2 ncr pearson prostate prostatic random secreto ser stroma sum transurethral us vascularization vessels volume	arborization bdnf chromodomain circuits complexity connections coordinately corepressor dendrite dendritic establishment ezh2 h3k27 interdependent knock knocking mechanistically morphogenesis neurodevelopment neurotrophic polycomb prc2 recruits repressive restrict shed throughput unleash unraveling
Tagcloud (Intersection) ?