REST and RCOR1

Number of citations of the paper that reports this interaction (PMID 10449787)
107

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		REST	RCOR1
Gene Name		RE1-silencing transcription factor	REST corepressor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Transcriptional Repressor Complex	Nucleus Nucleoplasm Transcriptional Repressor Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Outward Rectifier Potassium Channel Activity Transcription Regulatory Region DNA Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Hematopoietic Progenitor Cell Differentiation Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Aldosterone Biosynthetic Process Cellular Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation By Host Of Viral Transcription Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Cardiac Muscle Cell Myoblast Differentiation Histone H4 Deacetylation Cellular Response To Electrical Stimulus Cellular Response To Glucocorticoid Stimulus Potassium Ion Transmembrane Transport Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Amniotic Stem Cell Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Blood Coagulation Viral Process Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Histone H4 Deacetylation
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones	Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21909106) Bleomycin sensitivity ( 21106707)	Platelet counts ( 22139419)
Protein-Protein Interactions		7 interactors: CDYL GTF2B HTT RCOR1 SIN3B SUB1 TBP	10 interactors: CTBP1 HDAC2 HIST3H3 KDM1A PHF21A REST SMARCE1 SNAI1 SUB1 ZMYM2
Entrez ID		5978	23186
HPRD ID		08990	09645
Ensembl ID		ENSG00000084093	ENSG00000089902
Uniprot IDs		Q13127	J3KN32 Q9UKL0
PDB IDs		2CZY	2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription Elongation From RNA Polymerase II Promoter Histone Modification Histone Deacetylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Deacetylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Elongation Regulation Of RNA Metabolic Process Neural Plate Formation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Spermatogenesis Male Gamete Generation Regulation Of Metabolic Process Viral Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Gamete Generation Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Regulation Of Protein Phosphatase Type 2A Activity Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Lactate Biosynthetic Process Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Paraxial Mesoderm Formation Negative Regulation Of Cellular Metabolic Process	Chromosome Organization Chromatin Modification Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Histone Modification Nitrogen Compound Metabolic Process Histone H4 Deacetylation Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Steroid Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Organelle Organization Biosynthetic Process Regulation Of Hormone Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Lipid Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Deacetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process
Tagcloud ?		areas bph cellular coefficient composition depends dpv equation glands granular histological mathematical mm2 morphometric mu2 ncr pearson prostate prostatic random secreto ser stroma sum transurethral us vascularization vessels volume	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates gfi gfi1b h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Difference) ?		areas bph cellular coefficient composition depends dpv equation glands granular histological mathematical mm2 morphometric mu2 ncr pearson prostate prostatic random secreto ser stroma sum transurethral us vascularization vessels volume	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates gfi gfi1b h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Intersection) ?