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REST
Gene Name
RE1-silencing transcription factor
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Transcriptional Repressor Complex
Molecular Function
Core Promoter Sequence-specific DNA Binding
Core Promoter Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Outward Rectifier Potassium Channel Activity
Transcription Regulatory Region DNA Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Hematopoietic Progenitor Cell Differentiation
Chromatin Organization
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cell Proliferation
Negative Regulation Of Gene Expression
Negative Regulation Of Aldosterone Biosynthetic Process
Cellular Response To Drug
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation By Host Of Viral Transcription
Negative Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Calcium Ion-dependent Exocytosis
Negative Regulation Of Insulin Secretion
Negative Regulation Of Neurogenesis
Cardiac Muscle Cell Myoblast Differentiation
Histone H4 Deacetylation
Cellular Response To Electrical Stimulus
Cellular Response To Glucocorticoid Stimulus
Potassium Ion Transmembrane Transport
Negative Regulation Of Cortisol Biosynthetic Process
Negative Regulation Of Dense Core Granule Biogenesis
Negative Regulation Of Mesenchymal Stem Cell Differentiation
Negative Regulation Of Amniotic Stem Cell Differentiation
Pathways
Chromatin modifying enzymes
Chromatin organization
HDACs deacetylate histones
Drugs
Diseases
GWAS
Age-related macular degeneration (
21909106
)
Bleomycin sensitivity (
21106707
)
Protein-protein Interactions
7 interactors:
CDYL
GTF2B
HTT
RCOR1
SIN3B
SUB1
TBP
Entrez ID
5978
HPRD ID
08990
Ensembl ID
ENSG00000084093
Uniprot IDs
Q13127
PDB IDs
2CZY
Enriched GO Terms of Interacting Partners
?
Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
RNA Biosynthetic Process
Heterocycle Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
RNA Metabolic Process
Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Transcription Elongation From RNA Polymerase II Promoter
Histone Modification
Histone Deacetylation
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Protein Deacetylation
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
DNA-templated Transcription, Elongation
Regulation Of RNA Metabolic Process
Neural Plate Formation
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Spermatogenesis
Male Gamete Generation
Regulation Of Metabolic Process
Viral Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Chromatin Modification
Serotonin Uptake
Lactate Biosynthetic Process From Pyruvate
Gamete Generation
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation
Regulation Of Protein Phosphatase Type 2A Activity
Chromatin Organization
Transcription Initiation From RNA Polymerase II Promoter
Quinolinate Biosynthetic Process
Negative Regulation Of Synaptic Transmission, Dopaminergic
Sexual Reproduction
Multicellular Organismal Reproductive Process
Multicellular Organism Reproduction
Lactate Biosynthetic Process
Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Paraxial Mesoderm Formation
Negative Regulation Of Cellular Metabolic Process
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