HRH4 and SERPINB7

Data Source: HiPPIP (Novel)

		HRH4	SERPINB7
Name		histamine receptor H4	serpin family B member 7
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse	Extracellular Space Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity Neurotransmitter Receptor Activity	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Regulation Of MAPK Cascade	Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet-derived Growth Factor Production
Pathways		Histamine receptors G alpha (i) signalling events	None
Drugs		Amitriptyline Clozapine Loxapine Chlorpromazine Amoxapine Doxepin Aripiprazole Pheniramine REV131 Histamine Mianserin	None
GWAS		Adult body size ( 32376654 ) Chronotype ( 30696823 ) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009 ) Lung cancer ( 34062886 ) Response to taxane treatment (docetaxel) ( 23006423 )	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Asthma ( 30929738 31361310 31619474 32296059 34103634 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Food allergy ( 29051540 ) Hen's egg allergy ( 29051540 ) Systolic blood pressure ( 29208002 )
Novel Interactors		2 novel interactors: ALMS1 SERPINB7	10 novel interactors: FBXO22 HRH4 OGDH PHLPP1 PIGN RELCH RNF152 SLC5A2 TAX1BP1 ZCCHC2
Interacting Genes		4 interacting genes: CCL16 GNA15 GNAI1 GNAO1	None recorded
Entrez ID		59340	8710
HPRD ID		06004	04524
Ensembl ID		ENSG00000134489	ENSG00000166396
Uniprot IDs		B2KJ49 Q9H3N8	A8K3Q8 O75635
PDB IDs		7YFC 7YFD 8HN8 8HOC 8JXT 8JXV 8JXW 8JXX 8YN9 8YNA	Not available
GO Terms Enriched among Interactors		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion GTPase Activity GTP Binding G Protein-coupled Receptor Binding Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion G Protein Activity Chemokine-mediated Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mu-type Opioid Receptor Binding Positive Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Protein Transport D2 Dopamine Receptor Binding Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Relaxation Of Smooth Muscle Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Secretion By Cell Regulation Of Insulin Secretion Adenylate Cyclase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Secretion Regulation Of Peptide Hormone Secretion Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Protein Localization Positive Regulation Of Glomerular Mesangial Cell Proliferation Leukocyte Migration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Microtubule-based Process Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Glomerular Mesangial Cell Proliferation Ciliary Basal Body Cellular Response To Forskolin Regulation Of Relaxation Of Muscle Response To Forskolin Positive Regulation Of Transforming Growth Factor Beta Production G Protein-coupled Acetylcholine Receptor Signaling Pathway	None