HRH4 and ALMS1

Data Source: HiPPIP (Novel)

		HRH4	ALMS1
Name		histamine receptor H4	ALMS1 centrosome and basal body associated protein
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse	Spindle Pole Nucleoplasm Cytoplasm Mitochondrion Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Ciliary Basal Body Cell Projection
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity Neurotransmitter Receptor Activity	Protein Binding
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Regulation Of MAPK Cascade	Endosomal Transport Regulation Of Centriole Replication Regulation Of Stress Fiber Assembly Positive Regulation Of Cold-induced Thermogenesis
Pathways		Histamine receptors G alpha (i) signalling events	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Amitriptyline Clozapine Loxapine Chlorpromazine Amoxapine Doxepin Aripiprazole Pheniramine REV131 Histamine Mianserin	None
Diseases		None	Alstrom syndrome (AS)
GWAS		Adult body size ( 32376654 ) Chronotype ( 30696823 ) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009 ) Lung cancer ( 34062886 ) Response to taxane treatment (docetaxel) ( 23006423 )	Age at voice drop ( 27182965 ) Blood metabolite levels ( 26401656 ) Chronic kidney disease ( 20383146 ) Creatinine levels ( 20383145 ) Estimated glomerular filtration rate ( 31451708 31015462 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Glomerular filtration rate ( 27588450 ) Glomerular filtration rate (creatinine) ( 26831199 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) High density lipoprotein cholesterol levels ( 33339817 ) Intelligence (MTAG) ( 29326435 ) Menarche (age at onset) ( 27182965 ) Metabolite levels ( 21931564 ) Metabolite levels (X-11787) ( 23934736 ) Retinitis pigmentosa ( 33514863 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 ) Serum metabolite levels ( 23093944 33031748 ) Urinary metabolite levels in chronic kidney disease ( 29545352 ) Urinary metabolite ratios in chronic kidney disease ( 29545352 ) Urinary metabolites (H-NMR features) ( 24586186 )
Novel Interactors		2 novel interactors: ALMS1 SERPINB7	4 novel interactors: CNOT7 ELN HRH4 SLC4A5
Interacting Genes		4 interacting genes: CCL16 GNA15 GNAI1 GNAO1	3 interacting genes: GTF2IRD1 LIG4 MEGF10
Entrez ID		59340	7840
HPRD ID		06004	06023
Ensembl ID		ENSG00000134489	ENSG00000116127
Uniprot IDs		B2KJ49 Q9H3N8	Q8TCU4
PDB IDs		7YFC 7YFD 8HN8 8HOC 8JXT 8JXV 8JXW 8JXX 8YN9 8YNA	Not available
GO Terms Enriched among Interactors		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion GTPase Activity GTP Binding G Protein-coupled Receptor Binding Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion G Protein Activity Chemokine-mediated Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mu-type Opioid Receptor Binding Positive Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Protein Transport D2 Dopamine Receptor Binding Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Relaxation Of Smooth Muscle Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Secretion By Cell Regulation Of Insulin Secretion Adenylate Cyclase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Secretion Regulation Of Peptide Hormone Secretion Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Protein Localization Positive Regulation Of Glomerular Mesangial Cell Proliferation Leukocyte Migration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Microtubule-based Process Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Glomerular Mesangial Cell Proliferation Ciliary Basal Body Cellular Response To Forskolin Regulation Of Relaxation Of Muscle Response To Forskolin Positive Regulation Of Transforming Growth Factor Beta Production G Protein-coupled Acetylcholine Receptor Signaling Pathway	None