SERPINB7 and FBXO22

		SERPINB7	FBXO22
Description		serpin family B member 7	F-box protein 22
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Nucleus Cytoplasm Cytosol Z Disc
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet-derived Growth Factor Production	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Nucleocytoplasmic Transport Cellular Response To Starvation Regulation Of Myotube Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 30929738 31361310 31619474 32296059 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Food allergy ( 29051540) Hen's egg allergy ( 29051540) Systolic blood pressure ( 29208002)	Creatinine levels ( 29403010) Urate levels in obese individuals ( 25811787)
Interacting Genes			1 interacting genes: SNAI1
Entrez ID		8710	26263
HPRD ID		04524	16437
Ensembl ID		ENSG00000166396	ENSG00000167196
Uniprot IDs		A8K3Q8 O75635	Q8NEZ5
PDB IDs			8S7D 8S7E 8UA3 8UA6
Enriched GO Terms of Interacting Partners?			Left/right Pattern Formation Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Glomerular Parietal Epithelial Cell Development Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Platelet-derived Growth Factor Production Regulation Of Platelet-derived Growth Factor Production Metanephric Part Of Ureteric Bud Development Regionalization Negative Regulation Of Vitamin D Biosynthetic Process Ciliary Basal Body Organization Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Glomerular Mesangial Cell Proliferation Regulation Of Germinal Center Formation Pattern Specification Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Cartilage Morphogenesis Regulation Of Vitamin Metabolic Process Positive Regulation Of Cell Proliferation Involved In Kidney Development Positive Regulation Of Tolerance Induction Sequence-specific DNA Binding Heterochromatin Organization Regulation Of Glomerular Mesangial Cell Proliferation Lung Epithelium Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Trophoblast Giant Cell Differentiation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Tolerance Induction Tolerance Induction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Biosynthetic Process Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Regulation Of T Cell Differentiation In Thymus Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Bicellular Tight Junction Assembly Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Steroid Metabolic Process Cardiac Epithelial To Mesenchymal Transition
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