SERPINB7 and SLC5A2

		SERPINB7	SLC5A2
Description		serpin family B member 7	solute carrier family 5 member 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	Low-affinity D-glucose:sodium Symporter Activity D-glucose:sodium Symporter Activity Protein Binding Alpha-glucoside Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Transmembrane Transporter Activity Metal Ion Binding D-glucose Transmembrane Transporter Activity
	Biological Process	Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet-derived Growth Factor Production	Alpha-glucoside Transport Carbohydrate Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Hexose Transmembrane Transport Renal D-glucose Absorption Transmembrane Transport D-glucose Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane D-glucose Transmembrane Transport
Pathways			Cellular hexose transport Defective SLC5A2 causes renal glucosuria (GLYS1)
Drugs			Dapagliflozin Canagliflozin Empagliflozin Ertugliflozin Sotagliflozin
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 30929738 31361310 31619474 32296059 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Food allergy ( 29051540) Hen's egg allergy ( 29051540) Systolic blood pressure ( 29208002)	Glucosuria ( 30476138) Glucosuria (mild) ( 30476138) Glucosuria (moderate to severe) ( 30476138)
Interacting Genes			1 interacting genes: AQP2
Entrez ID		8710	6524
HPRD ID		04524	08919
Ensembl ID		ENSG00000166396	ENSG00000140675
Uniprot IDs		A8K3Q8 O75635	P31639 Q8WY15
PDB IDs			7VSI 7YNJ 7YNK 8HB0 8HDH 8HEZ 8HG7 8HIN
Enriched GO Terms of Interacting Partners?			Lumenal Side Of Membrane Cellular Response To Mercury Ion Cellular Response To Water Deprivation Glycerol Transmembrane Transporter Activity Positive Regulation Of Platelet-derived Growth Factor Production Regulation Of Platelet-derived Growth Factor Production Polyol Transmembrane Transport Renal Water Transport Response To Water Deprivation Glycerol Transmembrane Transport Water Transmembrane Transporter Activity Metanephric Collecting Duct Development Response To Mercury Ion Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Cell Proliferation Involved In Kidney Development Response To Water Regulation Of Glomerular Mesangial Cell Proliferation Collecting Duct Development Water Channel Activity Renal Water Homeostasis Positive Regulation Of Transforming Growth Factor Beta Production Cellular Response To Copper Ion Positive Regulation Of Collagen Biosynthetic Process Water Transport Multicellular Organismal-level Water Homeostasis Fluid Transport Response To Copper Ion Channel Activity Regulation Of Collagen Biosynthetic Process Carbohydrate Transmembrane Transport Regulation Of Collagen Metabolic Process Carbohydrate Transport Transport Vesicle Membrane Protein Homotetramerization Multicellular Organismal-level Chemical Homeostasis Serine-type Endopeptidase Inhibitor Activity Protein Tetramerization Peptidase Inhibitor Activity Renal System Process Recycling Endosome Organic Hydroxy Compound Transport Cellular Response To Metal Ion Cytoplasmic Vesicle Membrane
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