SERPINB7 and HRH4

		SERPINB7	HRH4
Description		serpin family B member 7	histamine receptor H4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	G Protein-coupled Receptor Activity Histamine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet-derived Growth Factor Production	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Regulation Of MAPK Cascade
Pathways			Histamine receptors G alpha (i) signalling events
Drugs			Amitriptyline Clozapine Loxapine Chlorpromazine Amoxapine Doxepin Aripiprazole Pheniramine REV131 Histamine Mianserin
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 30929738 31361310 31619474 32296059 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Food allergy ( 29051540) Hen's egg allergy ( 29051540) Systolic blood pressure ( 29208002)	Adult body size ( 32376654) Chronotype ( 30696823) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Lung cancer ( 34062886) Response to taxane treatment (docetaxel) ( 23006423)
Interacting Genes			4 interacting genes: CCL16 GNA15 GNAI1 GNAO1
Entrez ID		8710	59340
HPRD ID		04524	06004
Ensembl ID		ENSG00000166396	ENSG00000134489
Uniprot IDs		A8K3Q8 O75635	B2KJ49 Q9H3N8
PDB IDs			7YFC 7YFD 8HN8 8HOC 8JXT 8JXV 8JXW 8JXX 8YN9 8YNA
Enriched GO Terms of Interacting Partners?			Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion GTPase Activity GTP Binding G Protein-coupled Receptor Binding Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion G Protein Activity Chemokine-mediated Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mu-type Opioid Receptor Binding Positive Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Protein Transport D2 Dopamine Receptor Binding Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Relaxation Of Smooth Muscle Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Secretion By Cell Regulation Of Insulin Secretion Adenylate Cyclase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Secretion Regulation Of Peptide Hormone Secretion Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Protein Localization Positive Regulation Of Glomerular Mesangial Cell Proliferation Leukocyte Migration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Microtubule-based Process Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Glomerular Mesangial Cell Proliferation Ciliary Basal Body Cellular Response To Forskolin Regulation Of Relaxation Of Muscle Response To Forskolin Positive Regulation Of Transforming Growth Factor Beta Production G Protein-coupled Acetylcholine Receptor Signaling Pathway
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