HRH4 and CCL16

Number of citations of the paper that reports this interaction (PubMedID 15265943)
0

Data Source:
HPRD (in vivo)

		HRH4	CCL16
Description		histamine receptor H4	C-C motif chemokine ligand 16
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GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity Neurotransmitter Receptor Activity	Cytokine Activity Protein Binding Chemokine Activity Chemoattractant Activity CCR Chemokine Receptor Binding
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Regulation Of MAPK Cascade	Chemotaxis Inflammatory Response Immune Response Cell Communication Cell-cell Signaling Positive Regulation Of Cell Migration Eosinophil Chemotaxis Positive Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Histamine receptors G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Amitriptyline Clozapine Loxapine Chlorpromazine Amoxapine Doxepin Aripiprazole Pheniramine REV131 Histamine Mianserin
Diseases
GWAS		Adult body size ( 32376654) Chronotype ( 30696823) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Lung cancer ( 34062886) Response to taxane treatment (docetaxel) ( 23006423)	Initial pursuit acceleration ( 29064472)
Interacting Genes		4 interacting genes: CCL16 GNA15 GNAI1 GNAO1	6 interacting genes: CCL5 CCR1 CCR5 CCR8 HRH4 UBQLN2
Entrez ID		59340	6360
HPRD ID		06004	03233
Ensembl ID		ENSG00000134489	ENSG00000275152
Uniprot IDs		B2KJ49 Q9H3N8	O15467
PDB IDs		7YFC 7YFD 8HN8 8HOC 8JXT 8JXV 8JXW 8JXX 8YN9 8YNA	5LTL 7SCT 8FK9
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion GTPase Activity GTP Binding G Protein-coupled Receptor Binding Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion G Protein Activity Chemokine-mediated Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mu-type Opioid Receptor Binding Positive Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Protein Transport D2 Dopamine Receptor Binding Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Relaxation Of Smooth Muscle Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Secretion By Cell Regulation Of Insulin Secretion Adenylate Cyclase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Secretion Regulation Of Peptide Hormone Secretion Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Protein Localization Positive Regulation Of Glomerular Mesangial Cell Proliferation Leukocyte Migration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Microtubule-based Process Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Glomerular Mesangial Cell Proliferation Ciliary Basal Body Cellular Response To Forskolin Regulation Of Relaxation Of Muscle Response To Forskolin Positive Regulation Of Transforming Growth Factor Beta Production G Protein-coupled Acetylcholine Receptor Signaling Pathway	Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Dendritic Cell Migration Dendritic Cell Chemotaxis C-C Chemokine Binding C-C Chemokine Receptor Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Chemokine (C-C Motif) Ligand 5 Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Cytokine-mediated Signaling Pathway Cell Chemotaxis Response To Cytokine Response To Peptide Negative Regulation Of Macrophage Apoptotic Process Chemotaxis Mononuclear Cell Migration G Protein-coupled Receptor Signaling Pathway Locomotion G Protein-coupled Receptor Activity Cellular Response To Cytokine Stimulus Leukocyte Chemotaxis Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Monocyte Chemotaxis Monocyte Chemotaxis Calcium-mediated Signaling Inflammatory Response Regulation Of Monocyte Chemotaxis Regulation Of Myeloid Cell Apoptotic Process Immune Response Cell-cell Signaling Leukocyte Migration Regulation Of Neuroinflammatory Response Signaling Calcium Ion Transport Cell Communication Negative Regulation Of Viral Genome Replication Defense Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Leukocyte Apoptotic Process Coreceptor Activity Chemokine Receptor Antagonist Activity Chemokine (C-C Motif) Ligand 5 Signaling Pathway CCR4 Chemokine Receptor Binding Intracellular Signaling Cassette External Side Of Plasma Membrane Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Cell Migration Chemokine (C-C Motif) Ligand 7 Binding
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