SERPINB7 and RNF152

		SERPINB7	RNF152
Description		serpin family B member 7	ring finger protein 152
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Lysosome Lysosomal Membrane Membrane Organelle Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet-derived Growth Factor Production	Protein Polyubiquitination Cytoplasmic Translation Protein Monoubiquitination Apoptotic Process Cellular Response To Starvation Positive Regulation Of Autophagy Protein Ubiquitination Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Response To Amino Acid Starvation
Pathways			E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 30929738 31361310 31619474 32296059 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Food allergy ( 29051540) Hen's egg allergy ( 29051540) Systolic blood pressure ( 29208002)	Estimated glomerular filtration rate ( 30604766 31015462) Glomerular filtration rate (creatinine) ( 26831199 28452372)
Interacting Genes			12 interacting genes: CROCC EBP GJA8 KIR2DL3 MYD88 RHEB TRAF6 TSPAN12 UBE2E1 UBE2N UBE2W UBE3A
Entrez ID		8710	220441
HPRD ID		04524	11514
Ensembl ID		ENSG00000166396	ENSG00000176641
Uniprot IDs		A8K3Q8 O75635	Q8N8N0
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of TORC1 Signaling Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of TOR Signaling Response To Virus Protein Monoubiquitination Interleukin-33-mediated Signaling Pathway TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity TOR Signaling Cellular Response To Nutrient Levels Antiviral Innate Immune Response Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Negative Regulation Of TOR Signaling Defense Response To Virus MyD88-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Post-translational Protein Modification Endolysosomal Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Non-canonical NF-kappaB Signal Transduction Post-translational Protein Modification Regulation Of DNA-binding Transcription Factor Activity Tissue Homeostasis Anatomical Structure Homeostasis Lipopolysaccharide-mediated Signaling Pathway Response To Nutrient Levels Regulation Of Protein Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Induced Systemic Resistance Intracellular Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Sperm Entry Positive Regulation Of Golgi Lumen Acidification
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