RBP4 and RPE65

Number of citations: 0 (PubMedID 15009723)
Data Source: HPRD (in vitro)

		RBP4	RPE65
Name		retinol binding protein 4	retinoid isomerohydrolase RPE65
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Protein-containing Complex Extracellular Exosome	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cell Body
	Molecular Function	Retinoid Binding Protein Binding Retinal Binding Retinol Binding Retinol Transmembrane Transporter Activity Protein-containing Complex Binding Molecular Carrier Activity	Phosphatidylserine Binding Beta-carotene 15,15'-dioxygenase Activity Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Isomerase Activity Phosphatidylcholine Binding Metal Ion Binding Retinol Isomerase Activity All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Cardiolipin Binding
	Biological Process	Retinoid Metabolic Process Eye Development Positive Regulation Of Immunoglobulin Production Gluconeogenesis Spermatogenesis Heart Development Visual Perception Phototransduction, Visible Light Male Gonad Development Response To Xenobiotic Stimulus Response To Muscle Activity Maintenance Of Gastrointestinal Epithelium Lung Development Positive Regulation Of Insulin Secretion Response To Retinoic Acid Response To Insulin Retinol Transport Retinol Metabolic Process Retinal Metabolic Process Glucose Homeostasis Response To Ethanol Embryonic Organ Morphogenesis Embryonic Skeletal System Development Cardiac Muscle Tissue Development Female Genitalia Morphogenesis Detection Of Light Stimulus Involved In Visual Perception Retina Development In Camera-type Eye Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Vagina Development Urinary Bladder Development Heart Trabecula Formation Vitamin A Import Into Cell	Retinoid Metabolic Process Retina Homeostasis Neural Retina Development Lipid Metabolic Process Vitamin A Metabolic Process Visual Perception Circadian Rhythm Response To Light Stimulus Retinol Metabolic Process Retinal Metabolic Process Camera-type Eye Development Detection Of Light Stimulus Involved In Visual Perception Zeaxanthin Biosynthetic Process
Pathways		The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport Defective visual phototransduction due to STRA6 loss of function	The canonical retinoid cycle in rods (twilight vision)
Drugs		Tretinoin	Voretigene neparvovec
Diseases		None	Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Blood protein levels ( 30072576 ) Optic disc area ( 31798171 ) Retinol levels ( 21878437 )	Facial morphology ( 31763980 ) Glaucoma (primary open-angle) ( 33627673 ) HDL cholesterol levels in HIV infection ( 33109212 ) Mortality in sepsis ( 27639821 ) Vertical cup-disc ratio ( 28073927 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Novel Interactors		1 novel interactors: TLL2	None recorded
Interacting Genes		7 interacting genes: ALB GRB2 LAMTOR5 RBBP6 RIPPLY3 RPE65 TTR	2 interacting genes: RBP4 SLC27A1
Entrez ID		5950	6121
HPRD ID		01580	01569
Ensembl ID		ENSG00000138207	ENSG00000116745
Uniprot IDs		P02753 Q5VY30	Q16518
PDB IDs		1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ 5NTY 5NU2 5NU6 5NU7 5NU8 5NU9 5NUA 5NUB 6QBA	Not available
GO Terms Enriched among Interactors		Protein-containing Complex Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Guanyl-nucleotide Exchange Factor Adaptor Activity Response To Radiation Grb2-EGFR Complex Terpenoid Metabolic Process All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity Retinoid Metabolic Process All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Zeaxanthin Biosynthetic Process Retinol Isomerase Activity Diterpenoid Metabolic Process Xanthophyll Metabolic Process Detection Of Light Stimulus Negative Regulation Of Skeletal Muscle Tissue Growth Isoprenoid Metabolic Process Carotenoid Metabolic Process Beta-carotene 15,15'-dioxygenase Activity Detection Of Abiotic Stimulus Negative Regulation Of Glomerular Filtration Ragulator Complex Neurotrophin TRKA Receptor Binding Vitamin A Metabolic Process Regulation Of Skeletal Muscle Tissue Growth	Lipid Import Into Cell Vitamin Transmembrane Transport Vitamin Transport Response To Insulin Retinol Transmembrane Transporter Activity Female Genitalia Morphogenesis Lipid Transport Vitamin A Import Into Cell Response To Peptide Hormone Terpenoid Transport Retinol Transport Urinary Bladder Development Biotin Import Across Plasma Membrane Biotin Transport Medium-chain Fatty Acid Transport Biotin Transmembrane Transporter Activity Long-chain Fatty Acid Import Across Plasma Membrane Oleoyl-CoA Ligase Activity Lipid Transport Across Blood-brain Barrier Glucose Import In Response To Insulin Stimulus Embryonic Retina Morphogenesis In Camera-type Eye Fatty Acid Transmembrane Transporter Activity Molecular Carrier Activity Retinoid Binding Import Into Cell Retinal Binding Response To Hormone Vagina Development Very Long-chain Fatty Acid-CoA Ligase Activity Efflux Transmembrane Transporter Activity Positive Regulation Of Heat Generation Arachidonate-CoA Ligase Activity Long-chain Fatty Acid Import Into Cell Adiponectin-activated Signaling Pathway Genitalia Morphogenesis Negative Regulation Of Cardiac Muscle Cell Proliferation Heart Trabecula Formation Retinol Binding Phototransduction, Visible Light Positive Regulation Of Triglyceride Biosynthetic Process Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transmembrane Transporter Activity Female Genitalia Development Retinal Metabolic Process D-glucose Import Regulation Of Triglyceride Biosynthetic Process Detection Of Light Stimulus Involved In Visual Perception Uterus Development Positive Regulation Of Triglyceride Metabolic Process Detection Of Visible Light