RBP4 and RIPPLY3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RBP4	RIPPLY3
Description		retinol binding protein 4	ripply transcriptional repressor 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Protein-containing Complex Extracellular Exosome	Nucleus
	Molecular Function	Retinoid Binding Protein Binding Retinal Binding Retinol Binding Retinol Transmembrane Transporter Activity Protein-containing Complex Binding Molecular Carrier Activity	Protein Binding
	Biological Process	Retinoid Metabolic Process Eye Development Positive Regulation Of Immunoglobulin Production Gluconeogenesis Spermatogenesis Heart Development Visual Perception Phototransduction, Visible Light Male Gonad Development Response To Xenobiotic Stimulus Response To Muscle Activity Maintenance Of Gastrointestinal Epithelium Lung Development Positive Regulation Of Insulin Secretion Response To Retinoic Acid Response To Insulin Retinol Transport Retinol Metabolic Process Retinal Metabolic Process Glucose Homeostasis Response To Ethanol Embryonic Organ Morphogenesis Embryonic Skeletal System Development Cardiac Muscle Tissue Development Female Genitalia Morphogenesis Detection Of Light Stimulus Involved In Visual Perception Retina Development In Camera-type Eye Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Vagina Development Urinary Bladder Development Heart Trabecula Formation Vitamin A Import Into Cell	Negative Regulation Of Transcription By RNA Polymerase II Heart Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Pharyngeal System Development
Pathways		The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport Defective visual phototransduction due to STRA6 loss of function
Drugs		Tretinoin
Diseases
GWAS		Blood protein levels ( 30072576) Optic disc area ( 31798171) Retinol levels ( 21878437)
Interacting Genes		7 interacting genes: ALB GRB2 LAMTOR5 RBBP6 RIPPLY3 RPE65 TTR	22 interacting genes: CEP76 COMMD1 CRTAP EIF4A1 EIF4A2 HSP90AA1 INCA1 MAP4K4 MCRS1 MLEC ORC2 PIP4P2 PSMB1 RBCK1 RBP4 RGPD6 RHOBTB3 SNRNP70 STXBP1 TIFA TRAF2 WASL
Entrez ID		5950	53820
HPRD ID		01580	10923
Ensembl ID		ENSG00000138207	ENSG00000183145
Uniprot IDs		P02753 Q5VY30	P57055
PDB IDs		1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ 5NTY 5NU2 5NU6 5NU7 5NU8 5NU9 5NUA 5NUB 6QBA
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Guanyl-nucleotide Exchange Factor Adaptor Activity Response To Radiation Grb2-EGFR Complex Terpenoid Metabolic Process All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity Retinoid Metabolic Process All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Zeaxanthin Biosynthetic Process Retinol Isomerase Activity Diterpenoid Metabolic Process Xanthophyll Metabolic Process Detection Of Light Stimulus Negative Regulation Of Skeletal Muscle Tissue Growth Isoprenoid Metabolic Process Carotenoid Metabolic Process Beta-carotene 15,15'-dioxygenase Activity Detection Of Abiotic Stimulus Negative Regulation Of Glomerular Filtration Ragulator Complex Neurotrophin TRKA Receptor Binding Vitamin A Metabolic Process Regulation Of Skeletal Muscle Tissue Growth
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