TLNRD1 and SH2B2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLNRD1	SH2B2
Description		talin rod domain containing 1	SH2B adaptor protein 2
Image
GO Annotations	Cellular Component	Stress Fiber	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane Membrane
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding
	Biological Process		B-1 B Cell Homeostasis Signal Transduction Insulin Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Brown Fat Cell Differentiation
Pathways			Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668) Myocardial infarction ( 33532862)	Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 31049640)
Interacting Genes		4 interacting genes: CCM2 LRP6 PICK1 SH2B2	42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13B EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417
Entrez ID		59274	10603
HPRD ID		11300	16097
Ensembl ID		ENSG00000140406	ENSG00000160999
Uniprot IDs		Q9H1K6	O14492
PDB IDs		6XZ3 6XZ4	1Q2H
Enriched GO Terms of Interacting Partners?		Wnt Signalosome Wnt-Frizzled-LRP5/6 Complex Midbrain Dopaminergic Neuron Differentiation Embryo Development Ending In Birth Or Egg Hatching Wnt Receptor Activity Signaling Receptor Binding Multicellular Organism Development Toxin Transmembrane Transporter Activity Kinase Inhibitor Activity Cellular Developmental Process Low-density Lipoprotein Particle Receptor Activity Neural Crest Formation Neural Crest Cell Differentiation Chordate Embryonic Development Cellular Response To Cholesterol Protein Localization To Membrane Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Membrane Curvature Sensor Activity Negative Regulation Of Actin Nucleation Neuronal Ion Channel Clustering Arp2/3 Complex Binding Dendritic Spine Maintenance Long-term Synaptic Depression Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity B-1 B Cell Homeostasis Venous Blood Vessel Morphogenesis Endothelial Tube Morphogenesis Pericardium Development Blood Vessel Endothelial Cell Differentiation Endothelium Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Sterol Response To Cholesterol Cell Surface Receptor Signaling Pathway Localization Within Membrane Protein Serine/threonine Kinase Inhibitor Activity Wnt-protein Binding Positive Regulation Of Receptor Internalization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Monoamine Transport Brown Fat Cell Differentiation B Cell Homeostasis Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Endothelial Cell Differentiation	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Phosphorylation Kinase Activity Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Modification Process Protein Autophosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transferase Activity ATP Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MAPK Cascade Regulation Of Signal Transduction Nucleotide Binding Receptor Complex Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Response To Growth Factor Fc Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of Gene Expression Epidermal Growth Factor Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Metabolic Process ERBB Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Component Organization Growth Hormone Receptor Signaling Pathway Via JAK-STAT Membrane Raft Protein Metabolic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Apoptotic Process
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