TLNRD1 and CCM2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TLNRD1	CCM2
Description		talin rod domain containing 1	CCM2 scaffold protein
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GO Annotations	Cellular Component	Stress Fiber	Cytoplasm Mitochondrion Protein-containing Complex
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Protein Binding
	Biological Process		Blood Vessel Development Vasculogenesis In Utero Embryonic Development Endothelial Cell Development Vasculature Development Endothelium Development Integrin-mediated Signaling Pathway Heart Development Multicellular Organism Growth Cell-cell Junction Organization Regulation Of Angiogenesis Inner Ear Development Venous Blood Vessel Morphogenesis Stress-activated MAPK Cascade Pericardium Development Blood Vessel Endothelial Cell Differentiation Endothelial Tube Morphogenesis
Pathways
Drugs
Diseases			Cerebral cavernous malformation
GWAS		Coronary artery disease ( 33020668) Myocardial infarction ( 33532862)	Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Myocardial infarction ( 33532862)
Interacting Genes		4 interacting genes: CCM2 LRP6 PICK1 SH2B2	5 interacting genes: HOXC8 POT1 SMURF1 SRPK2 TLNRD1
Entrez ID		59274	83605
HPRD ID		11300	09719
Ensembl ID		ENSG00000140406	ENSG00000136280
Uniprot IDs		Q9H1K6	B7Z8D5 Q9BSQ5
PDB IDs		6XZ3 6XZ4	4FQN 4TVQ 4WJ7 4Y5O 4YKC 4YKD 4YL6
Enriched GO Terms of Interacting Partners?		Wnt Signalosome Wnt-Frizzled-LRP5/6 Complex Midbrain Dopaminergic Neuron Differentiation Embryo Development Ending In Birth Or Egg Hatching Wnt Receptor Activity Signaling Receptor Binding Multicellular Organism Development Toxin Transmembrane Transporter Activity Kinase Inhibitor Activity Cellular Developmental Process Low-density Lipoprotein Particle Receptor Activity Neural Crest Formation Neural Crest Cell Differentiation Chordate Embryonic Development Cellular Response To Cholesterol Protein Localization To Membrane Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Membrane Curvature Sensor Activity Negative Regulation Of Actin Nucleation Neuronal Ion Channel Clustering Arp2/3 Complex Binding Dendritic Spine Maintenance Long-term Synaptic Depression Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity B-1 B Cell Homeostasis Venous Blood Vessel Morphogenesis Endothelial Tube Morphogenesis Pericardium Development Blood Vessel Endothelial Cell Differentiation Endothelium Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Sterol Response To Cholesterol Cell Surface Receptor Signaling Pathway Localization Within Membrane Protein Serine/threonine Kinase Inhibitor Activity Wnt-protein Binding Positive Regulation Of Receptor Internalization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Monoamine Transport Brown Fat Cell Differentiation B Cell Homeostasis Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Endothelial Cell Differentiation	Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Engulfment Of Target By Autophagosome Nuclear Speck Organization Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding Shelterin Complex Activin Receptor Binding R-loop Processing Telomerase Inhibitor Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly DEAD/H-box RNA Helicase Binding Establishment Of Protein Localization To Telomere Substrate Localization To Autophagosome G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly
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