RANGAP1 and SUMO3

Number of citations of the paper that reports this interaction (PubMedID 16620772)
0

Data Source:
HPRD (in vivo)

		RANGAP1	SUMO3
Description		Ran GTPase activating protein 1	small ubiquitin like modifier 3
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Aggresome Dendrite Nuclear Membrane Nuclear Pore Cytoplasmic Filaments Perinuclear Region Of Cytoplasm Mitotic Spindle SUMO Ligase Complex Axon Cytoplasm Cytoplasmic Periphery Of The Nuclear Pore Complex	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body
	Molecular Function	RNA Binding GTPase Activator Activity Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Cadherin Binding	Protein Binding Protein Tag Activity Ubiquitin-like Protein Ligase Binding
	Biological Process	Signal Transduction Protein Sumoylation Negative Regulation Of Protein Export From Nucleus Response To Axon Injury Nuclear Export Cellular Response To Peptide Hormone Stimulus Activation Of GTPase Activity Cellular Response To Vasopressin	Protein Sumoylation Negative Regulation Of DNA Binding Regulation Of Protein Localization To Nucleus
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation SUMOylation of nuclear envelope proteins	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Bitter beverage consumption ( 31046077) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Lamb consumption ( 32066663) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 25056061 28991256 29483656) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Delirium ( 29631748)
Interacting Genes		23 interacting genes: AXIN2 CCL5 CDK1 CDK2 CSNK2A1 DLC1 GNAI1 GNAI3 IPO8 MUL1 OGT PDGFRL PTEN RAN RANBP2 SENP1 SENP2 SUMO1 SUMO2 SUMO3 UBE2E3 UBE2I USPL1	62 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A COPS5 CUL3 DAXX EGLN3 FAM221A FOS HIPK1 HIPK2 HOMEZ HSF1 HSF2 JUN KALRN MAPKAPK3 MORC3 PAX6 PCGF2 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAD54L2 RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SNRNP70 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1 ZBTB33 ZBTB39 ZCCHC12 ZMYM2 ZNF451 ZNF496
Entrez ID		5905	6612
HPRD ID		03839	03754
Ensembl ID		ENSG00000100401	ENSG00000184900
Uniprot IDs		P46060 Q9BSK3	P55854
PDB IDs		1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2IO2 2IO3 2IY0 3UIN 3UIO 3UIP 5D2M 9B62	1U4A 2IO1 2MP2 6K5R 6NNQ 7R2E 7ZJU
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Proteolysis SUMO Transferase Activity Regulation Of Protein Catabolic Process Presynaptic Cytosol Postsynaptic Cytosol DeSUMOylase Activity Nuclear Pore Protein Desumoylation Nucleoplasm Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Catabolic Process Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Tag Activity Protein Localization To Organelle Cyclin-dependent Protein Kinase Activity Ubiquitin-like Protein Ligase Binding Positive Regulation Of Proteolysis Magnesium Ion Binding SUMO Ligase Complex Nuclear Envelope Positive Regulation Of Metabolic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Small Protein Activating Enzyme Binding SUMO-specific Endopeptidase Activity Protein Modification By Small Protein Removal Nuclear Transport Nucleocytoplasmic Transport Regulation Of Protein Localization Regulation Of Protein Transport Histone Kinase Activity Nuclear Export Cytosol Regulation Of Cell Junction Assembly Negative Regulation Of Metabolic Process Regulation Of Intracellular Transport Cell Division Signal Transduction	PML Body Protein Sumoylation Nucleus Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Modification Process Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process SUMO Binding SMAD Protein Signal Transduction Cellular Response To Stress SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Postsynaptic Cytosol Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Transcription Corepressor Activity Positive Regulation Of Macromolecule Metabolic Process DeSUMOylase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Protein Sumoylation Protein Desumoylation Transcription Coregulator Activity Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Presynaptic Cytosol
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