RANGAP1 and USPL1

Number of citations of the paper that reports this interaction (PubMedID 37712884)
55

Data Source:
BioGRID (enzymatic study)

		RANGAP1	USPL1
Description		Ran GTPase activating protein 1	ubiquitin specific peptidase like 1
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Aggresome Dendrite Nuclear Membrane Nuclear Pore Cytoplasmic Filaments Perinuclear Region Of Cytoplasm Mitotic Spindle SUMO Ligase Complex Axon Cytoplasm Cytoplasmic Periphery Of The Nuclear Pore Complex	Extracellular Space Nucleus Cajal Body
	Molecular Function	RNA Binding GTPase Activator Activity Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Cadherin Binding	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO Binding Ubiquitin Binding
	Biological Process	Signal Transduction Protein Sumoylation Negative Regulation Of Protein Export From Nucleus Response To Axon Injury Nuclear Export Cellular Response To Peptide Hormone Stimulus Activation Of GTPase Activity Cellular Response To Vasopressin	Proteolysis Cell Population Proliferation SnRNA Transcription Protein Desumoylation Cajal Body Organization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation SUMOylation of nuclear envelope proteins
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Bitter beverage consumption ( 31046077) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Lamb consumption ( 32066663) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 25056061 28991256 29483656) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Metabolite levels ( 23823483)
Interacting Genes		23 interacting genes: AXIN2 CCL5 CDK1 CDK2 CSNK2A1 DLC1 GNAI1 GNAI3 IPO8 MUL1 OGT PDGFRL PTEN RAN RANBP2 SENP1 SENP2 SUMO1 SUMO2 SUMO3 UBE2E3 UBE2I USPL1	6 interacting genes: RANGAP1 SP100 SUMO1 SUMO2 SUMO3 TSC2
Entrez ID		5905	10208
HPRD ID		03839	09833
Ensembl ID		ENSG00000100401	ENSG00000132952
Uniprot IDs		P46060 Q9BSK3	A8K1B1 B3KQ64 Q5W0Q7
PDB IDs		1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2IO2 2IO3 2IY0 3UIN 3UIO 3UIP 5D2M 9B62	7P99 7ZJU 7ZJV
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Proteolysis SUMO Transferase Activity Regulation Of Protein Catabolic Process Presynaptic Cytosol Postsynaptic Cytosol DeSUMOylase Activity Nuclear Pore Protein Desumoylation Nucleoplasm Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Catabolic Process Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Tag Activity Protein Localization To Organelle Cyclin-dependent Protein Kinase Activity Ubiquitin-like Protein Ligase Binding Positive Regulation Of Proteolysis Magnesium Ion Binding SUMO Ligase Complex Nuclear Envelope Positive Regulation Of Metabolic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Small Protein Activating Enzyme Binding SUMO-specific Endopeptidase Activity Protein Modification By Small Protein Removal Nuclear Transport Nucleocytoplasmic Transport Regulation Of Protein Localization Regulation Of Protein Transport Histone Kinase Activity Nuclear Export Cytosol Regulation Of Cell Junction Assembly Negative Regulation Of Metabolic Process Regulation Of Intracellular Transport Cell Division Signal Transduction	Protein Sumoylation Protein Tag Activity PML Body Ubiquitin-like Protein Ligase Binding Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Intracellular Transport Negative Regulation Of Protein Export From Nucleus Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Protein Transport Negative Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Protein Transport Negative Regulation Of DNA Binding Maintenance Of Protein Location In Nucleus Protein Modification By Small Protein Conjugation Negative Regulation Of Protein Localization Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Protein Export From Nucleus Regulation Of Intracellular Transport Post-translational Protein Modification Maintenance Of Protein Localization In Organelle Ubiquitin Protein Ligase Binding Regulation Of Protein Localization Regulation Of DNA Binding Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Negative Regulation Of Transport Regulation Of Protein Transport Maintenance Of Location Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nuclear Pore Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Cytoplasmic Periphery Of The Nuclear Pore Complex Protein Metabolic Process Regulation Of Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Modification Process TSC1-TSC2 Complex Protein Localization To Nuclear Pore Regulation Of Protein Localization To Nucleus SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments Kinetochore
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