PIH1D2 and IGF2BP3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PIH1D2	IGF2BP3
Description		PIH1 domain containing 2	insulin like growth factor 2 mRNA binding protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm R2TP Complex Protein Folding Chaperone Complex Ribonucleoprotein Complex	P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Protein Binding Small GTPase Binding	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Regulator Activity MRNA 5'-UTR Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	Box C/D SnoRNP Assembly RRNA Processing Protein Stabilization	Regulation Of Cytokine Production Translation Regulation Of Translation Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Translation MRNA Transport CRD-mediated MRNA Stabilization
Pathways			Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Appendicular lean mass ( 33097823) Birth weight ( 27680694 31043758) Height ( 20881960 23563607 25282103 28552196) Hip circumference adjusted for BMI ( 25673412 34021172) Infant length ( 25281659) Offspring birth weight ( 31043758) Personality dimensions ( 23903073) Tau burden ( 33426524) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)
Interacting Genes		69 interacting genes: ANKRD11 BAG3 BANP CBLL2 CBX8 CCNL2 CDC23 CDCA8 CDKL3 CFAP206 COMMD3 CT55 CTAG1A CTAG1B DES DPH3 DSCAM EIF4A2 EXOSC5 FRS3 GFAP GMCL1 GPRASP2 HES7 HSF4 IGF2BP3 IQUB ITGB3BP KRTAP12-2 KRTAP12-4 LAP3 LMNB1 MCCD1 MDFI MED20 MISP MRFAP1L1 MVP NFIL3 NHSL2 NOTO NTAQ1 NXF1 PBX4 PLEKHJ1 POLR1C PRDM6 PRMT3 RALA REL RSPO4 SDCBP SERTAD1 SLPI SPRED1 SSX3 SUOX TAF6 TASOR2 TBATA TCEA2 TNNI1 TTC23 ZBTB1 ZMAT5 ZNF185 ZNF417 ZNF438 ZNF688	86 interacting genes: ANXA1 CEBPA DUX4 FOXP1 MEOX2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MKRN2 NEIL3 NFATC3 OGT PCBP1 PIH1D2 UBXN7 USP7 WEE2-AS1
Entrez ID		120379	10643
HPRD ID		14021	16306
Ensembl ID		ENSG00000150773	ENSG00000136231
Uniprot IDs		Q8WWB5	O00425
PDB IDs			2E44 6FQ1 6FQR 6GQE 6GX6
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Negative Regulation Of Cell Migration Regulation Of Macromolecule Metabolic Process RNA Destabilization Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Developmental Process Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Translation Regulation Of MRNA Stability Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Regulation Of Locomotion Negative Regulation Of Signal Transduction Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Space
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