SYTL1 and RAB27B

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		SYTL1	RAB27B
Description		synaptotagmin like 1	RAB27B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Microvillus Membrane Melanosome Extracellular Exosome Exocytic Vesicle	Endosome Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Synaptic Vesicle Membrane Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Exocytic Vesicle Axon Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding Neurexin Family Protein Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Intracellular Protein Transport Exocytosis	Exocytosis Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways		TBC/RABGAPs	Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS			Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		7 interacting genes: AKT1 NCF1 NCF2 NRXN1 RAB27A RAB27B RAB8A	10 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 UNC13D
Entrez ID		84958	5874
HPRD ID		12156	04846
Ensembl ID		ENSG00000142765	ENSG00000041353
Uniprot IDs		Q8IYJ3	O00194
PDB IDs			2F7S
Enriched GO Terms of Interacting Partners?		Myosin V Binding Establishment Of Protein Localization Protein Localization To Synapse Phagolysosome GDP Binding Protein Localization To Cell Junction Superoxide-generating NADPH Oxidase Activator Activity Superoxide-generating NAD(P)H Oxidase Activity Secretion By Cell NADPH Oxidase Complex Trans-Golgi Network Transport Vesicle Vesicle-mediated Transport Secretion Localization Within Membrane Respiratory Burst Superoxide Anion Generation Phosphatidylinositol-3,4-bisphosphate Binding Exocytosis Multivesicular Body Membrane Exocytic Vesicle Establishment Of Protein Localization To Membrane Cellular Localization Establishment Of Localization In Cell Superoxide Metabolic Process Multivesicular Body Sorting Pathway Receptor Localization To Synapse Cellular Defense Response Protein Localization To Membrane Intracellular Protein Localization GTPase Activity Establishment Of Protein Localization To Plasma Membrane Electron Transfer Activity Protein Localization To Cilium Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Calcium Ion Regulation Of TRNA Methylation GTP Binding Neuronal Cell Body Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway G Protein Activity Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Positive Regulation Of Protein Localization To Cell Periphery Protein Transport Positive Regulation Of Exocytosis Positive Regulation Of Protein Localization To Membrane Vesicle-mediated Transport In Synapse	Small GTPase Binding Exocytic Vesicle Neurexin Family Protein Binding Intracellular Protein Transport Positive Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Cellular Localization Protein Transport Establishment Of Localization In Cell Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Melanosome Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Myosin Binding Regulation Of Secretion Positive Regulation Of Protein Secretion Regulation Of Vesicle Fusion Regulation Of Insulin Secretion Regulation Of Calcium Ion-dependent Exocytosis Deoxyhypusine Synthase Activity Forebrain Generation Of Neurons Regulation Of Peptide Hormone Secretion Positive Regulation Of Transport Transport Vesicle Membrane Intracellular Protein Localization Cytoplasmic Vesicle Cortical Actin Cytoskeleton Spermidine Catabolic Process Positive Regulation Of Protein Transport Granuloma Formation Regulation Of Vesicle-mediated Transport Zinc Ion Binding Regulation Of Hormone Secretion Regulation Of Protein Secretion Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Timing Of Neuron Differentiation Polyamine Catabolic Process Amygdala Development Structural Constituent Of Tooth Enamel
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