GRIK4 and GRIK2

Number of citations of the paper that reports this interaction (PubMedID 12954862)
34

Data Source:
HPRD (in vivo)

		GRIK4	GRIK2
Description		glutamate ionotropic receptor kainate type subunit 4	glutamate ionotropic receptor kainate type subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane	Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Axon Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Neuronal Cell Body Terminal Bouton Perikaryon Synapse Postsynaptic Membrane Mossy Fiber Rosette Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	SNARE Binding Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Extracellularly Glutamate-gated Ion Channel Activity Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity PDZ Domain Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Identical Protein Binding Scaffold Protein Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential	Behavioral Fear Response Monoatomic Ion Transport Intracellular Calcium Ion Homeostasis Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Neuronal Action Potential Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Neuron Apoptotic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Presynaptic Membrane Potential Detection Of Cold Stimulus Involved In Thermoception
Pathways		Activation of Ca-permeable Kainate Receptor	Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor
Drugs		Glutamic acid Butabarbital Topiramate	Glutamic acid Butabarbital Butalbital Topiramate Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Domoic Acid Quisqualic acid 2s,4r-4-Methylglutamate
Diseases			Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Attention deficit hyperactivity disorder ( 23728934) Cognitive performance ( 20125193) Lateral ventricle volume ( 31530798) Post bronchodilator FEV1 in COPD ( 26634245)	A body shape index ( 34021172) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Biochemical measures ( 19260141) Cardiac hypertrophy ( 21348951) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Emphysema imaging phenotypes ( 26030696) Heart rate response to recovery post exercise (20 sec) ( 29497042) Longevity (90 years and older) ( 25199915) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) levels ( 23362303) Pursuit maintenance gain ( 29064472) Renal function-related traits (eGRFcrea) ( 22797727) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Waist circumference adjusted for body mass index ( 34021172) Weight ( 28552196)
Interacting Genes		4 interacting genes: GRIK1 GRIK2 GRIK3 RAB5A	20 interacting genes: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK1 GRIK4 GRIK5 GRIP1 LIN7B NETO1 PICK1 PRKAA1 SDCBP TRIM25
Entrez ID		2900	2898
HPRD ID		02613	00692
Ensembl ID		ENSG00000149403	ENSG00000164418
Uniprot IDs		A0A8D9PH79 A0A8D9UJ88 A6H8K8 B2RAP6 Q16099	A0A8D9PH75 A8K0H7 Q13002 Q8IY40
PDB IDs			3QXM 5CMM
Enriched GO Terms of Interacting Partners?		Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity Glutamate-gated Receptor Activity Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Terminal Bouton Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Negative Regulation Of Synaptic Transmission, Glutamatergic Presynaptic Membrane Glutamate Receptor Activity Monoatomic Ion Channel Activity Calcium-mediated Signaling Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Postsynaptic Membrane Dendrite Cytoplasm Regulation Of Long-term Neuronal Synaptic Plasticity Signaling Receptor Activity Regulation Of Presynaptic Membrane Potential Chemical Synaptic Transmission Trans-synaptic Signaling Negative Regulation Of Synaptic Transmission Synaptic Signaling Axon Regulation Of Membrane Potential Regulation Of Neuronal Synaptic Plasticity Dendrite Cell-cell Signaling Cell Surface Receptor Signaling Pathway Signaling Cell Communication Mossy Fiber Rosette Detection Of Cold Stimulus Involved In Thermoception Extracellularly Glutamate-gated Ion Channel Activity Monoatomic Ion Transmembrane Transport Perikaryon Intracellular Signaling Cassette Regulation Of Biological Quality Monoatomic Ion Transport Synapse Protein Localization To Early Endosome Regulation Of Synaptic Plasticity Ionotropic Glutamate Receptor Complex	Postsynaptic Density Membrane Synapse Postsynaptic Membrane Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Cell-cell Junction Presynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Cell-cell Signaling Signaling Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Cell Communication Adherens Junction Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Membrane Potential AMPA Glutamate Receptor Complex Protein Localization To Membrane Ionotropic Glutamate Receptor Binding Protein Localization To Cell Junction Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Plasma Membrane Localization Within Membrane Neuron Projection Intracellular Protein Localization Regulation Of Postsynaptic Membrane Potential Glutamate-gated Receptor Activity Basolateral Plasma Membrane Regulation Of Transport Postsynaptic Density Phosphatase Binding Regulation Of Biological Quality Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Cell-cell Adhesion Protein-containing Complex Localization Monoatomic Ion Channel Activity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
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