MID1IP1 and MID1

Number of citations of the paper that reports this interaction (PubMedID 15070402)
43

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MID1IP1	MID1
Description		MID1 interacting protein 1	midline 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Microtubule Cytoskeleton Centriolar Satellite
	Molecular Function	Protein Binding Enzyme Activator Activity Identical Protein Binding Ligase Regulator Activity	Protein Binding Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Phosphoprotein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Metabolic Process Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Protein Polymerization Positive Regulation Of Ligase Activity	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Intracellular Signal Transduction
Pathways		Carnitine shuttle	Interferon gamma signaling
Drugs
Diseases			Opitz-GBBB syndrome
GWAS		Response to metformin (IC50) ( 28173075)
Interacting Genes		7 interacting genes: AK8 APOE GSK3B MID1 MID2 SUFU TSHR	46 interacting genes: BYSL CDC37 CRY2 DYRK4 EHHADH ELOA EPN2 FAM50B FKBP1A GMCL1 HMG20B HTT IGBP1 KIF9 MEOX1 MID1IP1 MID2 N4BP1 OTUB2 PAX6 PDE4B PKN1 PPM1A PPP2CA PPP2CB PTCD2 PTPA RIC8A SPAG5 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2L6 UBE2N UBE2V1 UBE2W UBTD1 ZNF618
Entrez ID		58526	4281
HPRD ID		06732	02047
Ensembl ID		ENSG00000165175	ENSG00000101871
Uniprot IDs		Q9NPA3	A0A087X255 A0A8I5KPE0 A0A8I5KR14 O15344
PDB IDs			2DQ5 2FFW 2JUN 5IM8 7QRY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phospholipid Efflux Tau Protein Binding Enzyme Binding Artery Development Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Response To Amyloid-beta Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Regulation Of Proteolysis Negative Regulation Of Protein Localization Regulation Of Long-term Synaptic Potentiation Cellular Response To Amyloid-beta Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Protein Localization To Nucleus Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Localization To Microtubule Protein Localization To Cytoskeleton Phosphoprotein Binding Cellular Response To Thyrotropin-releasing Hormone Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Regulation Of Axon Extension Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Host-mediated Perturbation Of Symbiont Process Positive Regulation Of Intracellular Signal Transduction Lipid Transport Involved In Lipid Storage Lipoprotein Particle Regulation Of Protein Transport Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Beta-catenin Binding Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Response To Thyrotropin-releasing Hormone Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Response To Drug Regulation Of Establishment Of Protein Localization Modulation Of Process Of Another Organism Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Protein Transport	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein K48-linked Ubiquitination Protein Ubiquitination Protein K11-linked Ubiquitination Protein Monoubiquitination ISG15 Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding ISG15-protein Conjugation Nucleus Nucleotide Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Macromolecule Metabolic Process Transferase Activity Protein Phosphatase Type 2A Complex Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Protein Binding UBC13-MMS2 Complex Regulation Of Metabolic Process Regulation Of Gene Expression Phosphoprotein Phosphatase Activity Cytosol Ubiquitin Conjugating Enzyme Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Proteolysis Negative Regulation Of Signal Transduction Regulation Of Protein Polyubiquitination Regulation Of Microtubule-based Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Ubiquitin Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Primary Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Ligase Complex
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