MID1IP1 and SUFU

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MID1IP1	SUFU
Gene Name		MID1 interacting protein 1	suppressor of fused homolog (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Microtubule Microtubule Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol Primary Cilium Ciliary Tip Ciliary Base
	Molecular Function	Protein C-terminus Binding	Transcription Corepressor Activity Signal Transducer Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding
	Biological Process	Lipid Metabolic Process Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Protein Polymerization Positive Regulation Of Ligase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Neural Tube Closure Heart Looping Regulation Of Transcription, DNA-templated Proteolysis Signal Transduction Multicellular Organismal Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Negative Regulation Of Transcription Factor Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Skin Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways			Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		6 interactors: AK8 APOE GSK3B MID1 MID2 SUFU	26 interactors: BTRC GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 LAMTOR3 LGALS3 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 STK36 ZNF219 ZNF263 ZNF446 ZNF747 ZNF764
Entrez ID		58526	51684
HPRD ID		06732	06124
Ensembl ID		ENSG00000165175	ENSG00000107882
Uniprot IDs		Q9NPA3	Q9UMX1
PDB IDs			1M1L
Enriched GO Terms of Interacting Partners?		Protein Localization To Microtubule Protein Localization To Cytoskeleton Cellular Protein Localization Negative Regulation Of Dendrite Development Protein Localization Positive Regulation Of Axon Extension Central Nervous System Development Cellular Localization Negative Regulation Of Transcription Factor Import Into Nucleus Regulation Of Neuronal Synaptic Plasticity Regulation Of Protein Catabolic Process Negative Regulation Of Transport Regulation Of Signal Transduction Regulation Of Axon Extension Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Biosynthetic Process Positive Regulation Of Axonogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of MAP Kinase Activity Protein Localization To Organelle Negative Regulation Of Intracellular Protein Transport Regulation Of Signaling Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Cellular Response To Cytokine Stimulus Regulation Of Dendrite Development Regulation Of MAPK Cascade Negative Regulation Of Intracellular Transport Positive Regulation Of Cell Growth Negative Regulation Of Neuron Projection Development Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis Regulation Of Cell Size Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Neurofibrillary Tangle Assembly Superior Temporal Gyrus Development Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Response To Cytokine Negative Regulation Of Cell Projection Organization Negative Regulation Of Cell Differentiation Maintenance Of Location In Cell	RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Smoothened Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Notochord Regression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Mammary Gland Morphogenesis Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Tube Morphogenesis Smoothened Signaling Pathway Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Ventral Midline Development Gland Development Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organ Formation Proximal/distal Pattern Formation Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Pituitary Gland Development Gland Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Mammary Gland Development Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Tagcloud ?			beta1 blots cck colorectal constructed counting enhances gli1 hedgehog hh ht29 infecting integrin interference invasion itgb1 kit lentiviral lentivirus malignancies migrating rnai shh sonic transwell unrelated vectors xenografted xenografting
Tagcloud (Difference) ?			beta1 blots cck colorectal constructed counting enhances gli1 hedgehog hh ht29 infecting integrin interference invasion itgb1 kit lentiviral lentivirus malignancies migrating rnai shh sonic transwell unrelated vectors xenografted xenografting
Tagcloud (Intersection) ?