TRAPPC2 and TRAPPC3

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		TRAPPC2	TRAPPC3
Name		trafficking protein particle complex subunit 2	trafficking protein particle complex subunit 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol TRAPP Complex Perinuclear Region Of Cytoplasm TRAPPII Protein Complex TRAPPIII Protein Complex	Golgi Membrane Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol TRAPP Complex Cis-Golgi Network Membrane TRAPPII Protein Complex TRAPPIII Protein Complex
	Molecular Function	Protein Binding Transmembrane Transporter Binding	Protein Binding
	Biological Process	Skeletal System Development Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Coating Vesicle-mediated Transport COPII Vesicle Coating Vesicle Tethering	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Coating Vesicle-mediated Transport Golgi Vesicle Transport COPII Vesicle Coating Vesicle Tethering
Pathways		COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
Drugs		None	Palmitic Acid Myristic acid S-palmitoyl-L-cysteine
Diseases		Spondyloepiphyseal dysplasia tarda	None
GWAS		No GWAS studies recorded	Glaucoma (primary open-angle) ( 33627673 ) Intraocular pressure ( 30054594 )
Interacting Genes		34 interacting genes: ABRA CLIC1 CLIC2 DAPK1 EIF3C ENO1 ENO3 EPS15L1 HLA-E INCA1 KCTD1 MBD3L1 MFHAS1 NICN1 NME4 NR5A1 PITX1 PYGM REPS1 SLC25A35 SNAPC5 SNCA TEPSIN TRAPPC3 TRAPPC3L TRAPPC4 TRAPPC6A TRAPPC6B TRAPPC9 UQCC2 ZBTB38 ZNF438 ZNF655 ZRANB1	8 interacting genes: APP CDC45 LIG4 PLEKHF2 TRAPPC2 TRAPPC2B TRAPPC2L TRAPPC6A
Entrez ID		6399	27095
HPRD ID		02189	11644
Ensembl ID		ENSG00000196459	ENSG00000054116
Uniprot IDs		P0DI81 P0DI82 Q6IBE5	A0A087WWM0 A0A087WYS5 O43617
PDB IDs		Not available	1SZ7 2C0J 2CFH 3KXC
GO Terms Enriched among Interactors		TRAPP Complex Vesicle Tethering TRAPPII Protein Complex Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport TRAPPIII Protein Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity COPII Vesicle Coating Golgi Vesicle Transport Protein Binding Cis-Golgi Network Membrane Vesicle-mediated Transport Vesicle Organization Intracellular Transport Establishment Of Localization In Cell	TRAPPIII Protein Complex TRAPP Complex COPII Vesicle Coating Vesicle Tethering Vesicle Coating TRAPPII Protein Complex Vesicle Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intracellular Transport Vesicle-mediated Transport Protein-containing Complex Assembly Golgi Vesicle Transport Protein-containing Complex Organization Cellular Localization Endoplasmic Reticulum Establishment Of Localization In Cell Cellular Component Assembly Perinuclear Region Of Cytoplasm Organelle Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Establishment Of Integrated Proviral Latency Mitotic DNA Replication Preinitiation Complex Assembly Endoplasmic Reticulum-Golgi Intermediate Compartment Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Viral Latency DNA Replication Preinitiation Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Ligase (ATP) Activity DNA Ligase IV Complex DNA Ligase Activity DNA Replication Preinitiation Complex Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling