EPN1 and REPS2

Number of citations of the paper that reports this interaction (PubMedID 9422736)
0

Data Source:
HPRD (in vitro, in vivo)

		EPN1	REPS2
Description		epsin 1	RALBP1 associated Eps domain containing 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Vesicle Coat	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Clathrin Binding Molecular Sequestering Activity	Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	In Utero Embryonic Development Endocytosis Notch Signaling Pathway Female Pregnancy Embryonic Organ Development Negative Regulation Of Sprouting Angiogenesis	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Protein-containing Complex Assembly
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Major depressive disorder ( 23377640)
Interacting Genes		24 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A ZBTB16	15 interacting genes: AR ASAP1 ASAP2 CDK1 CDK5RAP2 EPN1 EPS15 GRB2 ITCH ITSN1 PXN RALB RALBP1 RELA REPS1
Entrez ID		29924	9185
HPRD ID		06270	02262
Ensembl ID		ENSG00000063245	ENSG00000169891
Uniprot IDs		Q9Y6I3	Q8NFH8
PDB IDs		1INZ 1KYD	1IQ3
Enriched GO Terms of Interacting Partners?		WW Domain Binding Clathrin-coated Pit Import Into Cell Sensory Perception Of Salty Taste Postsynaptic Neurotransmitter Receptor Internalization Clathrin Coat Of Coated Pit Sensory Perception Of Sour Taste Cellular Response To Vasopressin Cellular Response To Aldosterone Sodium Channel Complex Postsynaptic Endocytic Zone AP-2 Adaptor Complex Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Response To Aldosterone Endocytosis Clathrin Adaptor Activity Endolysosome Membrane Cellular Response To Acidic PH Receptor Internalization Clathrin Coat Assembly Clathrin-coated Vesicle Receptor-mediated Endocytosis Intracellular Sodium Ion Homeostasis Clathrin-coated Endocytic Vesicle Sodium Ion Import Across Plasma Membrane Response To Acidic PH Cellular Response To PH Vesicle-mediated Transport In Synapse Multicellular Organismal-level Water Homeostasis Apical Plasma Membrane Clathrin-dependent Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Homeostasis Response To Mineralocorticoid Synaptic Vesicle Endocytosis Response To PH Cytosolic Transport Presynaptic Endocytosis Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Clathrin Light Chain Binding Cellular Response To Corticosteroid Stimulus Clathrin-coated Endocytic Vesicle Membrane Vesicle-mediated Transport Clathrin Adaptor Complex Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Multicellular Organismal-level Chemical Homeostasis	Endocytosis Receptor-mediated Endocytosis Import Into Cell Positive Regulation Of Cellular Component Organization Receptor Internalization Clathrin-coated Pit Cytosol Vesicle-mediated Transport Positive Regulation Of Organelle Organization Regulation Of Schwann Cell Differentiation Regulation Of Cellular Component Organization Plasma Membrane Postsynaptic Endocytic Zone Protein-macromolecule Adaptor Activity Cytoplasm Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Signaling Cellular Response To Reactive Oxygen Species SH3 Domain Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway RNA Polymerase II Core Promoter Sequence-specific DNA Binding Symbiont Entry Into Host Cell Response To Oxidative Stress Regulation Of Signal Transduction Response To Reactive Oxygen Species Biological Process Involved In Interaction With Host Regulation Of Organelle Organization Endosome Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Cytoskeleton Organization Prostate Induction Positive Regulation Of Metabolic Process Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Male Somatic Sex Determination Pronuclear Fusion Cellular Response To Oxidative Stress Centrosome Cycle Positive Regulation Of Cellular Component Biogenesis Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Exocyst Assembly Doxorubicin Transport Transcription Coactivator Binding
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