EPN1 and SCNN1B

Number of citations of the paper that reports this interaction (PubMedID 16574660)
0

Data Source:
BioGRID (pull down)

		EPN1	SCNN1B
Description		epsin 1	sodium channel epithelial 1 subunit beta
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Vesicle Coat	Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Sodium Channel Complex Extracellular Exosome
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Clathrin Binding Molecular Sequestering Activity	Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	In Utero Embryonic Development Endocytosis Notch Signaling Pathway Female Pregnancy Embryonic Organ Development Negative Regulation Of Sprouting Angiogenesis	Leukocyte Activation Involved In Inflammatory Response Neutrophil Activation Involved In Immune Response Renal System Process Monoatomic Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Artery Smooth Muscle Contraction Response To Food Aldosterone Metabolic Process Erythrocyte Homeostasis Monoatomic Ion Transmembrane Transport Multicellular Organism Growth Sodium Ion Transmembrane Transport Epithelial Fluid Transport Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Potassium Ion Homeostasis Sodium Ion Homeostasis Mucus Secretion Neutrophil-mediated Killing Of Bacterium Cellular Response To Acidic PH Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Cellular Response To Vasopressin
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Stimuli-sensing channels Sensory perception of salty taste
Drugs		1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate	Triamterene Amiloride
Diseases			Liddle syndrome Bronchiectasis with or without elevated sweat chloride Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Major depressive disorder ( 23377640)	Kidney stones ( 31729369)
Interacting Genes		24 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A ZBTB16	14 interacting genes: ANK3 CNTN1 COMMD10 EPN1 HECW1 ITCH NEDD4 NEDD4L NFASC SCNN1A SCNN1D SCNN1G STX1A WWP2
Entrez ID		29924	6338
HPRD ID		06270	02861
Ensembl ID		ENSG00000063245	ENSG00000168447
Uniprot IDs		Q9Y6I3	B2R812 H3BQ95 P51168
PDB IDs		1INZ 1KYD	6BQN 6WTH 9BLR 9BTG 9BTU
Enriched GO Terms of Interacting Partners?		WW Domain Binding Clathrin-coated Pit Import Into Cell Sensory Perception Of Salty Taste Postsynaptic Neurotransmitter Receptor Internalization Clathrin Coat Of Coated Pit Sensory Perception Of Sour Taste Cellular Response To Vasopressin Cellular Response To Aldosterone Sodium Channel Complex Postsynaptic Endocytic Zone AP-2 Adaptor Complex Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Response To Aldosterone Endocytosis Clathrin Adaptor Activity Endolysosome Membrane Cellular Response To Acidic PH Receptor Internalization Clathrin Coat Assembly Clathrin-coated Vesicle Receptor-mediated Endocytosis Intracellular Sodium Ion Homeostasis Clathrin-coated Endocytic Vesicle Sodium Ion Import Across Plasma Membrane Response To Acidic PH Cellular Response To PH Vesicle-mediated Transport In Synapse Multicellular Organismal-level Water Homeostasis Apical Plasma Membrane Clathrin-dependent Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Homeostasis Response To Mineralocorticoid Synaptic Vesicle Endocytosis Response To PH Cytosolic Transport Presynaptic Endocytosis Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Clathrin Light Chain Binding Cellular Response To Corticosteroid Stimulus Clathrin-coated Endocytic Vesicle Membrane Vesicle-mediated Transport Clathrin Adaptor Complex Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Multicellular Organismal-level Chemical Homeostasis	Negative Regulation Of Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Sensory Perception Of Salty Taste Negative Regulation Of Potassium Ion Transport Import Into Cell Negative Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Aldosterone Sodium Channel Complex Sensory Perception Of Sour Taste Cellular Response To Vasopressin Potassium Channel Inhibitor Activity Transmembrane Transporter Binding Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Sodium Ion Transport Negative Regulation Of Cation Transmembrane Transport Response To Aldosterone Negative Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Acidic PH Regulation Of Potassium Ion Transport Intracellular Sodium Ion Homeostasis Inorganic Cation Import Across Plasma Membrane Negative Regulation Of Monoatomic Ion Transport Response To Acidic PH Ubiquitin-protein Transferase Activity Cellular Response To PH Negative Regulation Of Transmembrane Transport Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Homeostasis Neuromuscular Junction Development Response To Mineralocorticoid Sodium Ion Transmembrane Transport Response To PH Import Across Plasma Membrane Regulation Of Metal Ion Transport Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Monoubiquitination Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Sodium Channel Inhibitor Activity Regulation Of Dendrite Morphogenesis Endocytosis Cellular Response To Corticosteroid Stimulus Receptor Internalization Protein K63-linked Ubiquitination
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