EPN1 and CRMP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EPN1	CRMP1
Description		epsin 1	collapsin response mediator protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Vesicle Coat	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Actin Cytoskeleton Dendrite Growth Cone Midbody Cell Projection Neuronal Cell Body Perikaryon Presynapse Postsynapse
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Clathrin Binding Molecular Sequestering Activity	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Filamin Binding Identical Protein Binding Phosphoprotein Binding
	Biological Process	In Utero Embryonic Development Endocytosis Notch Signaling Pathway Female Pregnancy Embryonic Organ Development Negative Regulation Of Sprouting Angiogenesis	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Semaphorin-plexin Signaling Pathway Regulation Of Postsynapse Assembly
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	CRMPs in Sema3A signaling
Drugs		1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Major depressive disorder ( 23377640)	Blood trace element (Zn levels) ( 23720494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		24 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A ZBTB16	81 interacting genes: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DISC1 DNAJB11 DPYSL2 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LRRK2 LSM2 MAP3K20 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RACK1 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RSPH1 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1 ZNF24
Entrez ID		29924	1400
HPRD ID		06270	03913
Ensembl ID		ENSG00000063245	ENSG00000072832
Uniprot IDs		Q9Y6I3	B3KT07 B3KV96 E9PD68 Q14194 Q96I11 X5DNI1
PDB IDs		1INZ 1KYD	4B3Z
Enriched GO Terms of Interacting Partners?		WW Domain Binding Clathrin-coated Pit Import Into Cell Sensory Perception Of Salty Taste Postsynaptic Neurotransmitter Receptor Internalization Clathrin Coat Of Coated Pit Sensory Perception Of Sour Taste Cellular Response To Vasopressin Cellular Response To Aldosterone Sodium Channel Complex Postsynaptic Endocytic Zone AP-2 Adaptor Complex Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Response To Aldosterone Endocytosis Clathrin Adaptor Activity Endolysosome Membrane Cellular Response To Acidic PH Receptor Internalization Clathrin Coat Assembly Clathrin-coated Vesicle Receptor-mediated Endocytosis Intracellular Sodium Ion Homeostasis Clathrin-coated Endocytic Vesicle Sodium Ion Import Across Plasma Membrane Response To Acidic PH Cellular Response To PH Vesicle-mediated Transport In Synapse Multicellular Organismal-level Water Homeostasis Apical Plasma Membrane Clathrin-dependent Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Homeostasis Response To Mineralocorticoid Synaptic Vesicle Endocytosis Response To PH Cytosolic Transport Presynaptic Endocytosis Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Clathrin Light Chain Binding Cellular Response To Corticosteroid Stimulus Clathrin-coated Endocytic Vesicle Membrane Vesicle-mediated Transport Clathrin Adaptor Complex Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Multicellular Organismal-level Chemical Homeostasis	Cytoplasm Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytosol Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding RNA Binding Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Protein Binding Protein-containing Complex Organization Organelle Organization Regulation Of Signal Transduction Cytoskeleton Organization Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Membrane Potential Cellular Component Assembly Nucleus Regulation Of Programmed Cell Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Binding Regulation Of MAPK Cascade Protein-containing Complex Assembly Regulation Of Apoptotic Process Perinuclear Region Of Cytoplasm BAT3 Complex Binding Regulation Of Wnt Signaling Pathway Regulation Of Mitochondrial Depolarization Catabolic Process Positive Regulation Of Autophagy Regulation Of Cellular Response To Stress Regulation Of Protein Metabolic Process Regulation Of CAMKK-AMPK Signaling Cascade Negative Regulation Of Hippo Signaling HULC Complex Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Branching Morphogenesis Of A Nerve Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Microtubule Cytoskeleton Organization
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