CTDSP1 and GTF2F1

Number of citations of the paper that reports this interaction (PMID 12721286)
49

Data Source:
HPRD (in vitro)

		CTDSP1	GTF2F1
Gene Name		CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	general transcription factor IIF, polypeptide 1, 74kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Extracellular Vesicular Exosome	Nucleus Nucleoplasm Transcription Factor TFIIF Complex Cell Junction
	Molecular Function	Protein Binding CTD Phosphatase Activity Metal Ion Binding	DNA Binding Transcription Coactivator Activity Catalytic Activity Protein Binding Transcription Factor Binding Phosphatase Activator Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Protein Dephosphorylation Negative Regulation Of Neuron Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Response To Virus Gene Expression Viral Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Catalytic Activity Positive Regulation Of Viral Transcription
Pathways			RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Influenza Life Cycle HIV elongation arrest and recovery HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Influenza Viral RNA Transcription and Replication RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Viral Messenger RNA Synthesis RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		6 interactors: CDCA3 GTF2F1 LDB1 MBP POLR2A SNAI1	31 interactors: ABL1 AHR AR ARNT ATF7IP CCNT1 CDK9 CSNK2A1 CTDP1 CTDSP1 FCP1 FEZ1 FOS GTF2A1 GTF2B GTF2E2 GTF2F2 GTF2H4 JUN KLF5 MAGEC1 MSX2 MYC PARP1 PSMC2 PTN SRF TAF1 TAF11 TBP TRIM27
Entrez ID		58190	2962
HPRD ID		05615	01803
Ensembl ID		ENSG00000144579	ENSG00000125651
Uniprot IDs		Q9GZU7	P35269
PDB IDs		1T9Z 1TA0 2GHQ 2GHT 3L0B 3L0C 3L0Y 3PGL	1F3U 1I27 1J2X 1NHA 1ONV 2K7L
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Differentiation Stem Cell Development 7-methylguanosine MRNA Capping Transcription From RNA Polymerase II Promoter 7-methylguanosine RNA Capping Stem Cell Differentiation Positive Regulation Of Viral Transcription Regulation Of DNA-templated Transcription, Elongation Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Positive Regulation Of Macromolecule Biosynthetic Process Hair Follicle Development Positive Regulation Of Gene Expression Hair Cycle Process Histone H3-K4 Acetylation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Hair Cycle Transcription, RNA-templated Positive Regulation Of Hemoglobin Biosynthetic Process Stem Cell Maintenance Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Defense Response To Nematode Gastrulation Transcription, DNA-templated Negative Regulation Of Vitamin D Biosynthetic Process Regulation Of Hemoglobin Biosynthetic Process DNA-templated Transcription, Initiation RNA Biosynthetic Process Skin Development MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Response To Nematode Positive Regulation Of Cellular Metabolic Process Epidermis Development Notch Signaling Involved In Heart Development Negative Regulation Of Erythrocyte Differentiation Regulation Of Tight Junction Assembly Positive Regulation Of Transcription, DNA-templated RNA Splicing Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Vitamin Metabolic Process Cerebellar Purkinje Cell Differentiation RNA Metabolic Process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Transcription, DNA-templated DNA-templated Transcription, Elongation RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Gene Expression DNA-templated Transcription, Initiation RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Viral Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Viral Transcription Regulation Of Nucleic Acid-templated Transcription Viral Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Viral Process Regulation Of Viral Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Cellular Component Organization Negative Regulation Of Biosynthetic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Proliferation
Tagcloud ?			akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?			akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
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