CTDSP1 and ZSWIM8

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		CTDSP1	ZSWIM8
Description		CTD small phosphatase 1	zinc finger SWIM-type containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Extracellular Exosome	Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity Phosphatase Activity Metal Ion Binding	Zinc Ion Binding Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Negative Regulation Of Neuron Differentiation Negative Regulation Of Neurogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Type I Interferon-mediated Signaling Pathway Target-directed MiRNA Degradation Positive Regulation Of MiRNA Catabolic Process
Pathways			Regulation of expression of SLITs and ROBOs
Drugs		Aspartate beryllium trifluoride Citric acid
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin concentration ( 27863252 32888494)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908)
Interacting Genes		43 interacting genes: ACTN3 BAG3 CDCA3 CDKN2C CRYBA2 CSF1R CSTF2T FAAP20 FAM110A FANCL FGFR2 GPSM1 GTF2F1 HUNK ITPKB LCK LDB1 LRRC73 LTBP4 MAPKBP1 MBP MORN3 NOXA1 OSTF1 PDZD4 PLEKHM1 POLR2A PTPN11 RAB3IL1 RPRD2 SAXO4 SCNM1 SDCBP SNAI1 STRA8 TEKT4 TRAPPC6A TYRO3 USP29 WWOX YPEL5 ZBTB16 ZSWIM8	5 interacting genes: ATN1 ATXN1 ATXN1L CTDSP1 PRMT2
Entrez ID		58190	23053
HPRD ID		05615	17199
Ensembl ID		ENSG00000144579	ENSG00000214655
Uniprot IDs		Q9GZU7	A7E2V4 S4R410
PDB IDs		1T9Z 1TA0 2GHQ 2GHT 3L0B 3L0C 3L0Y 3PGL 4YGY 4YH1 6DU3
Enriched GO Terms of Interacting Partners?			POZ Domain Binding Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Social Behavior Lung Alveolus Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Histone H3R8 Methyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Memory Nuclear Matrix Nuclear Progesterone Receptor Binding Nucleoplasm Regulation Of G1/S Transition Of Mitotic Cell Cycle Learning Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nucleolus Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Brain Development RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Negative Regulation Of Macromolecule Metabolic Process Protein-arginine N-methyltransferase Activity Negative Regulation Of Cell Cycle Process Poly(G) Binding Learning Or Memory Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Proliferation Transcription Coactivator Activity Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Peroxisome Proliferator Activated Receptor Binding Regulation Of Macromolecule Metabolic Process Cognition Nuclear Inclusion Body Regulation Of Mitotic Cell Cycle Phase Transition
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