CTDSP1 and CDCA3

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		CTDSP1	CDCA3
Description		CTD small phosphatase 1	cell division cycle associated 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Extracellular Exosome	Cytoplasm Cytosol Adherens Junction
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity Phosphatase Activity Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Negative Regulation Of Neuron Differentiation Negative Regulation Of Neurogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Ubiquitination Cell Division
Pathways
Drugs		Aspartate beryllium trifluoride Citric acid
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin concentration ( 27863252 32888494)
Interacting Genes		43 interacting genes: ACTN3 BAG3 CDCA3 CDKN2C CRYBA2 CSF1R CSTF2T FAAP20 FAM110A FANCL FGFR2 GPSM1 GTF2F1 HUNK ITPKB LCK LDB1 LRRC73 LTBP4 MAPKBP1 MBP MORN3 NOXA1 OSTF1 PDZD4 PLEKHM1 POLR2A PTPN11 RAB3IL1 RPRD2 SAXO4 SCNM1 SDCBP SNAI1 STRA8 TEKT4 TRAPPC6A TYRO3 USP29 WWOX YPEL5 ZBTB16 ZSWIM8	10 interacting genes: APP BCL11A CTDSP1 CTDSP2 CUL1 SKP1 TRAF1 TRAF2 UBC WEE1
Entrez ID		58190	83461
HPRD ID		05615	09670
Ensembl ID		ENSG00000144579	ENSG00000111665
Uniprot IDs		Q9GZU7	F5GX58 F8WDL1 J3KMY0 Q99618
PDB IDs		1T9Z 1TA0 2GHQ 2GHT 3L0B 3L0C 3L0Y 3PGL 4YGY 4YH1 6DU3
Enriched GO Terms of Interacting Partners?			Protein Modification Process Ubiquitin Ligase Complex Scaffold Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Thioesterase Binding Protein Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Post-translational Protein Modification Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Molecular Function Activator Activity Cell Death Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Tumor Necrosis Factor Receptor Binding Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Negative Regulation Of Cell Cycle Phase Transition Protein Ubiquitination Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Epithelial Cell Apoptotic Process Protein Monoubiquitination Protein Polyubiquitination SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway TORC2 Complex Disassembly Negative Regulation Of Cell Cycle Process Negative Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Neuron Remodeling TORC1 Signaling Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Phosphatase Activity
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