PVR and TIGIT

Number of citations of the paper that reports this interaction (PMID 21982860)
4

Data Source:
BioGRID (pull down)

		PVR	TIGIT
Gene Name		poliovirus receptor	T cell immunoreceptor with Ig and ITIM domains
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Virus Receptor Activity Receptor Activity Protein Binding Cell Adhesion Molecule Binding	Receptor Binding Protein Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Virus Viral Process Single Organismal Cell-cell Adhesion Cell Migration Cell Junction Assembly Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell-cell Junction Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Susceptibility To T Cell Mediated Cytotoxicity	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of T Cell Activation
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		18 interactors: AP1M2 CD226 CD96 DYNLT1 DYNLT3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 NOTCH2NL PLA2G3 PVRL1 PVRL3 SLC30A2 TIGIT TNFRSF12A VTN WNK1	4 interactors: PVR PVRL2 PVRL3 PVRL4
Entrez ID		5817	201633
HPRD ID		01434	08804
Ensembl ID		ENSG00000073008	ENSG00000181847
Uniprot IDs		P15151	Q495A1
PDB IDs		1DGI 1NN8 3EPC 3EPD 3EPF 3UDW 3URO 4FQP	3Q0H 3RQ3 3UCR 3UDW
Enriched GO Terms of Interacting Partners?		Cell Adhesion Lens Morphogenesis In Camera-type Eye Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Immune System Process Positive Regulation Of Sequestering Of Zinc Ion Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Adherens Junction Organization Lens Development In Camera-type Eye Anatomical Structure Morphogenesis Cell Differentiation Interaction With Host Organelle Localization Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Wound Healing Camera-type Eye Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Intracellular Transport Of Viral Protein In Host Cell Transport Regulation Of Sequestering Of Zinc Ion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Viral Process Eye Morphogenesis Retina Development In Camera-type Eye Enamel Mineralization Positive Regulation Of Immune Response To Tumor Cell Immune Response Viral Life Cycle Developmental Process Immune System Process Cell Junction Assembly Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Sperm Axoneme Assembly Tooth Mineralization Cell-cell Junction Organization Cell-substrate Adhesion Positive Regulation Of Systemic Arterial Blood Pressure Lipoxygenase Pathway Desmosome Organization Cell Adhesion Mediated By Integrin Positive Regulation Of Mast Cell Activation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Phosphatidylglycerol Acyl-chain Remodeling Acrosome Assembly Amelogenesis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway	Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Cell Adhesion Viral Entry Into Host Cell Entry Into Host Cell Cellular Component Assembly Viral Process Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Interaction With Host Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of Adaptive Immune Response Fertilization Sperm Mitochondrion Organization Positive Regulation Of Innate Immune Response Viral Life Cycle Regulation Of Adaptive Immune Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Fusion Of Virus Membrane With Host Plasma Membrane Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Innate Immune Response Response To Virus Virion Attachment To Host Cell Adhesion Of Symbiont To Host Positive Regulation Of Mast Cell Activation Acrosome Assembly Establishment Of Mitochondrion Localization Single Organismal Cell-cell Adhesion Positive Regulation Of Immune Response Spermatid Nucleus Differentiation Lens Morphogenesis In Camera-type Eye Response To Other Organism Response To Biotic Stimulus Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Mast Cell Activation Mitochondrion Localization
Tagcloud ?		advance catheterization collaborative consensus epoprostenol glaxo hemodynamic investigators mailed multicenter nc nineteen optimize output page pap park pph pulmonary responded routinely scheduled survey thirds triangle unresponsive vasodilator wellcome worsening	abolish adapter asn227 disrupts dramatically engagement granule harbors immunoglobulin immunoreceptor itim itt killer killing ligation motif motifs nk phosphatidylinositol polarization poliovirus prematurely pvr recruit restoration ship1 tail terminate tyr225
Tagcloud (Difference) ?		advance catheterization collaborative consensus epoprostenol glaxo hemodynamic investigators mailed multicenter nc nineteen optimize output page pap park pph pulmonary responded routinely scheduled survey thirds triangle unresponsive vasodilator wellcome worsening	abolish adapter asn227 disrupts dramatically engagement granule harbors immunoglobulin immunoreceptor itim itt killer killing ligation motif motifs nk phosphatidylinositol polarization poliovirus prematurely recruit restoration ship1 tail terminate tyr225
Tagcloud (Intersection) ?		pvr