PVR and NECTIN3

Number of citations of the paper that reports this interaction (PubMedID 12759359)
0

Data Source:
HPRD (in vitro)

		PVR	NECTIN3
Description		PVR cell adhesion molecule	nectin cell adhesion molecule 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane	Plasma Membrane Cell-cell Junction Adherens Junction Membrane Axon Dendrite Apical Junction Complex Cell-cell Contact Zone Synapse Postsynaptic Membrane Anchoring Junction Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Signaling Receptor Activity Receptor Ligand Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity
	Biological Process	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Natural Killer Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity	Lens Morphogenesis In Camera-type Eye Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Fertilization Symbiont Entry Into Host Cell Retina Morphogenesis In Camera-type Eye Establishment Of Protein Localization To Plasma Membrane Cochlea Morphogenesis Cell-cell Adhesion Regulation Of Postsynapse Assembly Protein Localization To Cell Junction
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Nectin/Necl trans heterodimerization	Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs		Sphingosine Myristic acid
Diseases
GWAS		Alzheimer's disease ( 24755620) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Mean platelet volume ( 27863252 32888494) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Platelet distribution width ( 32888494)	Feeling hurt ( 29500382)
Interacting Genes		68 interacting genes: ADIPOQ ANKRD46 AP1M2 AQP10 BRICD5 C3orf52 CD226 CD47 CD96 CLDN19 CTXN3 CYB561A3 CYSRT1 DYNLT1 DYNLT3 EBP EDDM3B GPRC5D HHATL HOXA1 INSIG2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-1 KRTAP3-3 KRTAP6-3 KRTAP9-3 MFSD11 NBPF19 NECTIN1 NECTIN3 NINJ1 NINJ2 NOTCH2NLA OLFM4 PGA4 PLA2G3 PLP2 PLPP6 RUSF1 SCD SLC30A2 SLC35B4 SLC41A2 SMIM1 SNAP47 SYS1 TAS2R19 TIGIT TM6SF2 TMBIM6 TMEM147 TMEM229B TMEM54 TMEM65 TMEM79 TSPO VAMP5 VTN WNK1 ZDHHC15 ZDHHC22 ZFPL1 ZFTRAF1	24 interacting genes: AFDN CYSRT1 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-1 KRTAP4-11 KRTAP4-2 KRTAP5-11 KRTAP5-9 KRTAP9-3 NBPF19 NECTIN1 NECTIN2 NOTCH2NLA OTX1 PARD3 PICK1 PVR RGS20 TIGIT
Entrez ID		5817	25945
HPRD ID		01434	08454
Ensembl ID		ENSG00000073008	ENSG00000177707
Uniprot IDs		A0A0A0MSA9 A0A0C4DG49 A8K4I1 P15151	Q9NQS3
PDB IDs		1DGI 1NN8 3EPC 3EPD 3EPF 3J8F 3J9F 3UDW 3URO 4FQP 6ARQ 6ISC 6O3O	4FOM
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Apical Junction Complex Membrane Cell Adhesion Mediator Activity Establishment Of Protein Localization To Membrane Identical Protein Binding Membrane Destabilizing Activity Regulation Of Natural Killer Cell Mediated Immunity Cell-cell Contact Zone Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cochlea Morphogenesis Regeneration Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Protein Binding Cell Adhesion Positive Regulation Of Mast Cell Activation Steroid Biosynthetic Process Cholesterol Biosynthetic Process	Intermediate Filament Keratin Filament Susceptibility To T Cell Mediated Cytotoxicity Cell-cell Contact Zone Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell Adhesion Molecule Binding Apical Junction Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Identical Protein Binding Cell Adhesion Mediator Activity Adherens Junction Leukocyte Mediated Cytotoxicity Hair Cycle Virus Receptor Activity Positive Regulation Of Immune Response To Tumor Cell Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Symbiont Entry Into Host Cell Lymphocyte Mediated Immunity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cytosol Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Positive Regulation Of T Cell Mediated Cytotoxicity Leukocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Tight Junction Diencephalon Morphogenesis Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Biological Process Involved In Interaction With Host Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Bicellular Tight Junction Assembly Regulation Of T Cell Mediated Cytotoxicity Cell-cell Junction Organization Cell Killing Tight Junction Assembly Tight Junction Organization Regulation Of Lymphocyte Mediated Immunity Sperm Mitochondrion Organization BBSome Binding Cell-cell Junction Coreceptor Activity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
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