PVR and PLA2G3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PVR	PLA2G3
Gene Name		poliovirus receptor	phospholipase A2, group III
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Centriole Plasma Membrane Mast Cell Granule
	Molecular Function	Virus Receptor Activity Receptor Activity Protein Binding Cell Adhesion Molecule Binding	Calcium Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Virus Viral Process Single Organismal Cell-cell Adhesion Cell Migration Cell Junction Assembly Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell-cell Junction Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Susceptibility To T Cell Mediated Cytotoxicity	Acrosome Assembly Phospholipid Metabolic Process Sperm Axoneme Assembly Lipid Catabolic Process Lipoxygenase Pathway Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Mast Cell Degranulation Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Cilium Morphogenesis
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Acyl chain remodelling of PG Acyl chain remodelling of PE Metabolism of lipids and lipoproteins Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)	Paclitaxel-induced neuropathy ( 23776197)
Protein-Protein Interactions		18 interactors: AP1M2 CD226 CD96 DYNLT1 DYNLT3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 NOTCH2NL PLA2G3 PVRL1 PVRL3 SLC30A2 TIGIT TNFRSF12A VTN WNK1	2 interactors: PVR TGFB1I1
Entrez ID		5817	50487
HPRD ID		01434	07144
Ensembl ID		ENSG00000073008	ENSG00000100078
Uniprot IDs		P15151	Q9NZ20
PDB IDs		1DGI 1NN8 3EPC 3EPD 3EPF 3UDW 3URO 4FQP
Enriched GO Terms of Interacting Partners?		Cell Adhesion Lens Morphogenesis In Camera-type Eye Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Immune System Process Positive Regulation Of Sequestering Of Zinc Ion Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Adherens Junction Organization Lens Development In Camera-type Eye Anatomical Structure Morphogenesis Cell Differentiation Interaction With Host Organelle Localization Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Wound Healing Camera-type Eye Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Intracellular Transport Of Viral Protein In Host Cell Transport Regulation Of Sequestering Of Zinc Ion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Viral Process Eye Morphogenesis Retina Development In Camera-type Eye Enamel Mineralization Positive Regulation Of Immune Response To Tumor Cell Immune Response Viral Life Cycle Developmental Process Immune System Process Cell Junction Assembly Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Sperm Axoneme Assembly Tooth Mineralization Cell-cell Junction Organization Cell-substrate Adhesion Positive Regulation Of Systemic Arterial Blood Pressure Lipoxygenase Pathway Desmosome Organization Cell Adhesion Mediated By Integrin Positive Regulation Of Mast Cell Activation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Phosphatidylglycerol Acyl-chain Remodeling Acrosome Assembly Amelogenesis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway	Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Adhesion Positive Regulation Of Epithelial To Mesenchymal Transition Androgen Receptor Signaling Pathway Viral Entry Into Host Cell Entry Into Host Cell Positive Regulation Of Stem Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Cytotoxicity Adherens Junction Organization Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Interaction With Host Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Killing Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Leukocyte Mediated Cytotoxicity Response To Heat Regulation Of Fat Cell Differentiation Positive Regulation Of Adaptive Immune Response Positive Regulation Of Cell Morphogenesis Involved In Differentiation Morphogenesis Of Embryonic Epithelium Positive Regulation Of Innate Immune Response Regulation Of Cellular Response To Growth Factor Stimulus Response To Temperature Stimulus Viral Life Cycle Regulation Of Adaptive Immune Response Intracellular Receptor Signaling Pathway Cell Junction Assembly Cell-cell Junction Organization
Tagcloud ?		advance catheterization collaborative consensus epoprostenol glaxo hemodynamic investigators mailed multicenter nc nineteen optimize output page pap park pph pulmonary responded routinely scheduled survey thirds triangle unresponsive vasodilator wellcome worsening
Tagcloud (Difference) ?		advance catheterization collaborative consensus epoprostenol glaxo hemodynamic investigators mailed multicenter nc nineteen optimize output page pap park pph pulmonary responded routinely scheduled survey thirds triangle unresponsive vasodilator wellcome worsening
Tagcloud (Intersection) ?