NGB and GNAI3

Number of citations of the paper that reports this interaction (PMID 12860983)
41

Data Source:
HPRD (in vitro)

		NGB	GNAI3
Gene Name		neuroglobin	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Perikaryon	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Oxygen Transporter Activity Iron Ion Binding Oxygen Binding Heme Binding	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding
	Biological Process	Apoptotic Process Oxygen Transport	Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division
Pathways			GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Major depressive disorder ( 20125088)
Protein-Protein Interactions		12 interactors: ATP1B2 C1orf94 CCDC36 FLOT1 GNAI1 GNAI2 GNAI3 GNAO1 L3MBTL3 REL TDO2 VAC14	40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR
Entrez ID		58157	2773
HPRD ID		05602	00765
Ensembl ID		ENSG00000165553
Uniprot IDs		A0M8W9 Q9NPG2	P08754 Q5TZX1
PDB IDs		1OJ6	2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Platelet Activation Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Response To Wounding Vesicle Fusion Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Organelle Fusion Regulation Of CAMP Biosynthetic Process Cell Division Regulation Of CAMP Metabolic Process Tryptophan Catabolic Process To Acetyl-CoA G-protein Coupled Receptor Signaling Pathway Response To Stress Positive Regulation Of Potassium Ion Import Membrane Fusion Synaptic Transmission Regulation Of Catalytic Activity Positive Regulation Of Sodium Ion Export From Cell Regulation Of Ion Transport Regulation Of Heart Contraction Cell Activation Sodium Ion Export From Cell Signaling Cell Communication Methotrexate Transport Regulation Of Calcium Ion Transport Sodium Ion Export Vesicle Organization Folic Acid Transport Cellular Potassium Ion Homeostasis Tryptophan Catabolic Process To Kynurenine Response To Stimulus Metabolic Process Membrane Organization Cellular Modified Amino Acid Metabolic Process Folic Acid Metabolic Process Kynurenine Metabolic Process Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Interleukin-12 Biosynthetic Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion
Tagcloud ?		advance atrophy bladder catheterization charts cic clean cystoscopies deal detrusor doi encountered ethnicity hydronephrosis intermittent manage neurogenic november publication regularly sci sensation sphincter spinal ultrasounds urethral urological veterans void	akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested
Tagcloud (Difference) ?		advance atrophy bladder catheterization charts cic clean cystoscopies deal detrusor doi encountered ethnicity hydronephrosis intermittent manage neurogenic november publication regularly sci sensation sphincter spinal ultrasounds urethral urological veterans void	akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested
Tagcloud (Intersection) ?