PTPRN2 and SPTBN4

Number of citations of the paper that reports this interaction (PMID 11086001)
55

Data Source:
HPRD (in vivo, two hybrid)

		PTPRN2	SPTBN4
Gene Name		protein tyrosine phosphatase, receptor type, N polypeptide 2	spectrin, beta, non-erythrocytic 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Lumen Integral Component Of Plasma Membrane Secretory Granule Transport Vesicle Membrane Terminal Bouton Receptor Complex	Cytoplasm Cytosol Plasma Membrane Adherens Junction Spectrin Membrane Nuclear Matrix PML Body Node Of Ranvier Paranode Region Of Axon Neuronal Cell Body Axon Initial Segment Axon Hillock Extracellular Vesicular Exosome Cell Body Fiber
	Molecular Function	Transmembrane Receptor Protein Tyrosine Phosphatase Activity	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatase Binding Ankyrin Binding Spectrin Binding
	Biological Process	Protein Dephosphorylation Negative Regulation Of GTPase Activity Peptidyl-tyrosine Dephosphorylation	Regulation Of Sodium Ion Transport Cytoskeletal Anchoring At Plasma Membrane Axonogenesis Axon Guidance Sensory Perception Of Sound Adult Walking Behavior Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Actin Filament Capping Cardiac Conduction Establishment Of Protein Localization To Plasma Membrane
Pathways			Interaction between L1 and Ankyrins Axon guidance L1CAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 21057379) Myopia (pathological) ( 23049088) Obesity-related traits ( 23251661) Response to amphetamines ( 22952603)
Protein-Protein Interactions		3 interactors: CKAP5 SPTBN4 UBQLN4	12 interactors: ANK3 CDC37 CELSR3 CENPU DISC1 GADD45A GSK3B NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6
Entrez ID		5799	57731
HPRD ID		03413	09372
Ensembl ID		ENSG00000155093	ENSG00000160460
Uniprot IDs		Q92932	C9JY79 Q9H254
PDB IDs		2QEP 4HTI 4HTJ
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Clustering Of Voltage-gated Sodium Channels Negative Regulation Of Heart Rate Cytoskeletal Anchoring At Plasma Membrane Neuronal Ion Channel Clustering	Cell Cycle Organelle Organization Axon Development Cytoskeleton Organization Locomotion Regulation Of Cellular Process Telencephalon Development Centrosome Cycle Nervous System Development Regulation Of Protein Localization Movement Of Cell Or Subcellular Component Maintenance Of Protein Location In Plasma Membrane Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Neuron Projection Development Multicellular Organismal Development Cell Projection Morphogenesis Cellular Response To Mechanical Stimulus Generation Of Neurons Cell Part Morphogenesis Anatomical Structure Development Axon Guidance Neurogenesis Negative Regulation Of Phosphorylation Neuron Development Signal Transduction In Response To DNA Damage Negative Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Delayed Rectifier Potassium Channel Activity Superior Temporal Gyrus Development Dense Core Granule Maturation Canonical Wnt Signaling Pathway Central Nervous System Development Signal Transduction Centrosome Organization Negative Regulation Of Binding Microtubule Cytoskeleton Organization Forebrain Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle Process Cell Morphogenesis Microtubule Organizing Center Organization Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Regulation Of Centriole-centriole Cohesion Developmental Process Protein Localization Neuron Differentiation Signaling Cell Projection Organization
Tagcloud ?		aldh1 castration cd45 circulation ctcs elasticity emt esr2 foxp3 highlighting igf2 incremental individually invasiveness microfiltration microfluidics micromanipulator noncancerous personalized postulate prognostication retrieved shed signatures smoothness stream tgfb3 transitioning wnt5a
Tagcloud (Difference) ?		aldh1 castration cd45 circulation ctcs elasticity emt esr2 foxp3 highlighting igf2 incremental individually invasiveness microfiltration microfluidics micromanipulator noncancerous personalized postulate prognostication retrieved shed signatures smoothness stream tgfb3 transitioning wnt5a
Tagcloud (Intersection) ?