PTPRE and TUBB4B

		PTPRE	TUBB4B
Description		protein tyrosine phosphatase receptor type E	tubulin beta 4B class IVb
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Axonemal Microtubule Cilium Microtubule Cytoskeleton Motile Cilium Azurophil Granule Lumen Sperm Flagellum Cell Projection Intercellular Bridge Extracellular Exosome Mitotic Spindle Extracellular Vesicle
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Identical Protein Binding	Nucleotide Binding Double-stranded RNA Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding MHC Class I Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Protein Dephosphorylation Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Regulation Of Mast Cell Activation Negative Regulation Of Insulin Receptor Signaling Pathway	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Flagellated Sperm Motility Natural Killer Cell Mediated Cytotoxicity
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Alendronic acid Tiludronic acid	Albendazole Mebendazole Epothilone D Patupilone Oxibendazole CYT997 Phenethyl Isothiocyanate
Diseases
GWAS		Response to amphetamines ( 22952603) Select biomarker traits ( 17903293) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		10 interacting genes: FYN GRB2 KCNA5 KCNB1 MAPK1 MAPK3 PTPRD PTPRS SRC YES1	23 interacting genes: ACD CDKN2A CEBPA DAPK1 DLEU1 DLST ENOX2 LINC01554 NEAT1 NEDD8 OGT POT1 PSME1 PTEN RSPH1 SCG2 SOCS6 SOCS7 SUMO2 TERF1 TINF2 TUBG1 WEE2-AS1
Entrez ID		5791	10383
HPRD ID		02956	04043
Ensembl ID		ENSG00000132334	ENSG00000188229
Uniprot IDs		A8K2Z9 P23469 Q96P81	P68371
PDB IDs		2JJD 6D3F 6D4D 6D4F	7UN1 7UNG 8J07 8SH7
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response T Cell Costimulation Phosphotyrosine Residue Binding Cellular Response To Transforming Growth Factor Beta Stimulus Epidermal Growth Factor Receptor Signaling Pathway Response To Transforming Growth Factor Beta Caveola ERBB Signaling Pathway Negative Regulation Of Immune Response Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Defense Response Cellular Response To Platelet-derived Growth Factor Stimulus Modulation Of Chemical Synaptic Transmission Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune Response-activating Cell Surface Receptor Signaling Pathway ERBB2 Signaling Pathway Protein Kinase Activity Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Negative Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Multicellular Organismal Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Interleukin-34-mediated Signaling Pathway Protein Tyrosine Kinase Activity Insulin-like Growth Factor Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Kinase Activity Regulation Of Immune System Process Transmembrane Transporter Binding Signal Transduction Protein Phosphorylation Immune Response-activating Signaling Pathway Regulation Of Golgi Inheritance Non-membrane Spanning Protein Tyrosine Kinase Activity Plasma Membrane Phosphorylation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Immune Effector Process Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Signaling Receptor Binding	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Proteolysis Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomere Organization Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cell Size Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Chromosome, Telomeric Region Chromosome Organization Organelle Organization Protein Tag Activity Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nuclear Body Organization DNA Biosynthetic Process SUMO Transferase Activity Nucleus Negative Regulation Of Metabolic Process Meiotic Spindle Organization Regulation Of Chromosome Organization Protein Modification Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Component Organization
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