PTPRE and KCNA5

Number of citations of the paper that reports this interaction (PMID 15588985)
37

Data Source:
HPRD (in vitro)

		PTPRE	KCNA5
Gene Name		protein tyrosine phosphatase, receptor type, E	potassium channel, voltage gated shaker related subfamily A, member 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Intercalated Disc Z Disc Potassium Channel Complex Membrane Raft Intracellular Canaliculus Perinuclear Region Of Cytoplasm
	Molecular Function	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Homodimerization Activity	Receptor Binding Delayed Rectifier Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Alpha-actinin Binding Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding
	Biological Process	Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Regulation Of Mast Cell Activation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway	Response To Hypoxia Potassium Ion Transport Synaptic Transmission Regulation Of Vasoconstriction Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Negative Regulation Of Potassium Ion Transport Regulation Of Insulin Secretion Protein Homooligomerization Negative Regulation Of Cytosolic Calcium Ion Concentration Potassium Ion Homeostasis Membrane Hyperpolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Potassium Ion Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Myoblast Proliferation
Pathways			Potassium Channels Voltage gated Potassium channels
Drugs
Diseases
GWAS		Response to amphetamines ( 22952603) Select biomarker traits ( 17903293)
Protein-Protein Interactions		10 interactors: FYN GRB2 KCNA5 KCNB1 MAPK1 MAPK3 PTPRD PTPRS SRC YES1	10 interactors: ACTN2 DLG1 DLG4 ERBB2IP KCNA2 PTPRE SNTA1 SRC SUMO3 TNK2
Entrez ID		5791	3741
HPRD ID		02956	08888
Ensembl ID		ENSG00000132334	ENSG00000130037
Uniprot IDs		P23469 Q96P81	P22460
PDB IDs		2JJD
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Hemostasis Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Response To Peptide Hormone Regulation Of Early Endosome To Late Endosome Transport Response To Platelet-derived Growth Factor Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway T Cell Costimulation Axonogenesis Cellular Response To Growth Factor Stimulus Axon Development Cellular Response To Hormone Stimulus Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Wound Healing Chemotaxis Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Positive Regulation Of Immune Response Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Cell Morphogenesis Involved In Differentiation Innate Immune Response Nervous System Development Neuron Projection Development	Regulation Of Membrane Potential Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Endocytosis Positive Regulation Of Potassium Ion Transport Cortical Cytoskeleton Organization Synaptic Transmission Cell-cell Junction Organization Muscle Contraction Actin Filament-based Process Regulation Of Sodium Ion Transmembrane Transport Peptidyl-tyrosine Autophosphorylation Muscle System Process Movement Of Cell Or Subcellular Component Receptor Clustering Nucleotide Phosphorylation Signaling Regulation Of Potassium Ion Transport Regulation Of Insulin Receptor Signaling Pathway Cell Communication Regulation Of Sodium Ion Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cell-cell Signaling Regulation Of Vesicle-mediated Transport Regulation Of Vasoconstriction By Circulating Norepinephrine Axon Guidance Regulation Of Cellular Response To Insulin Stimulus Cellular Component Assembly Protein Complex Assembly Action Potential Regulation Of Cellular Localization Adherens Junction Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Activation Cytoskeleton Organization Optic Nerve Structural Organization Basal Protein Localization Cellular Response To Progesterone Stimulus Cell Projection Organization Cell Adhesion Regulation Of Cellular Process Regulation Of Receptor Activity
Tagcloud ?		amplifications begin breakpoints copy csgalnact2 dataset dhx57 differing disruptions driver entity expand faf1 g34r h3f3a hgg icna intragenic k27m kcnd2 kidins220 map4k3 nf1 paediatric phgg rb1 ret suppressors tmem178	advance channel doi es ewing gated hypoxic kv kv1 nb onc online overexpress pcg polycomb potassium prerequisite publication reasoned relapse remission repression repressive resist restore sensitizes survive tumorigenicity voltage
Tagcloud (Difference) ?		amplifications begin breakpoints copy csgalnact2 dataset dhx57 differing disruptions driver entity expand faf1 g34r h3f3a hgg icna intragenic k27m kcnd2 kidins220 map4k3 nf1 paediatric phgg rb1 ret suppressors tmem178	advance channel doi es ewing gated hypoxic kv kv1 nb onc online overexpress pcg polycomb potassium prerequisite publication reasoned relapse remission repression repressive resist restore sensitizes survive tumorigenicity voltage
Tagcloud (Intersection) ?