PTPRE and KCNA5

Number of citations of the paper that reports this interaction (PubMedID 10921884)
54

Data Source:
HPRD (in vitro)

		PTPRE	KCNA5
Description		protein tyrosine phosphatase receptor type E	potassium voltage-gated channel subfamily A member 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane	Golgi Apparatus Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Cell Surface Intercalated Disc Membrane Z Disc Monoatomic Ion Channel Complex Potassium Channel Complex Membrane Raft Intracellular Canaliculus Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Identical Protein Binding	Signaling Receptor Binding Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Protein Kinase Binding Alpha-actinin Binding Voltage-gated Potassium Channel Activity Involved In Bundle Of His Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Repolarization Scaffold Protein Binding
	Biological Process	Protein Dephosphorylation Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Regulation Of Mast Cell Activation Negative Regulation Of Insulin Receptor Signaling Pathway	Action Potential Response To Hypoxia Monoatomic Ion Transport Potassium Ion Transport Notch Signaling Pathway Response To Mechanical Stimulus Regulation Of Vasoconstriction Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Response To Hydrogen Peroxide Regulation Of Insulin Secretion Protein Complex Oligomerization Protein Homooligomerization Negative Regulation Of Cytosolic Calcium Ion Concentration Potassium Ion Homeostasis Transmembrane Transport Response To Hyperoxia Membrane Hyperpolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Potassium Ion Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Bundle Of His Cell Action Potential Membrane Repolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Myoblast Proliferation
Pathways			Voltage gated Potassium channels Phase 3 - rapid repolarisation
Drugs		Alendronic acid Tiludronic acid	Enflurane Promethazine Miconazole Vernakalant Dalfampridine Isavuconazole
Diseases			Atrial fibrillation
GWAS		Response to amphetamines ( 22952603) Select biomarker traits ( 17903293) Triglyceride levels x loop diuretics use interaction ( 31806883)	Femur bone mineral density x serum urate levels interaction ( 34046847) Longevity ( 30294719)
Interacting Genes		10 interacting genes: FYN GRB2 KCNA5 KCNB1 MAPK1 MAPK3 PTPRD PTPRS SRC YES1	11 interacting genes: ACTN2 DLG1 DLG4 ERBIN KCNA2 PTPRE SNTA1 SRC TMEM107 TNK2 UBE2I
Entrez ID		5791	3741
HPRD ID		02956	08888
Ensembl ID		ENSG00000132334	ENSG00000130037
Uniprot IDs		A8K2Z9 P23469 Q96P81	P22460
PDB IDs		2JJD 6D3F 6D4D 6D4F
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response T Cell Costimulation Phosphotyrosine Residue Binding Cellular Response To Transforming Growth Factor Beta Stimulus Epidermal Growth Factor Receptor Signaling Pathway Response To Transforming Growth Factor Beta Caveola ERBB Signaling Pathway Negative Regulation Of Immune Response Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Defense Response Cellular Response To Platelet-derived Growth Factor Stimulus Modulation Of Chemical Synaptic Transmission Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune Response-activating Cell Surface Receptor Signaling Pathway ERBB2 Signaling Pathway Protein Kinase Activity Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Negative Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Multicellular Organismal Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Interleukin-34-mediated Signaling Pathway Protein Tyrosine Kinase Activity Insulin-like Growth Factor Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Kinase Activity Regulation Of Immune System Process Transmembrane Transporter Binding Signal Transduction Protein Phosphorylation Immune Response-activating Signaling Pathway Regulation Of Golgi Inheritance Non-membrane Spanning Protein Tyrosine Kinase Activity Plasma Membrane Phosphorylation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Immune Effector Process Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Signaling Receptor Binding	Regulation Of Membrane Potential Cell Junction Anchoring Junction Neuromuscular Junction Glutamatergic Synapse Ionotropic Glutamate Receptor Binding Transmembrane Transporter Binding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Transport Juxtaparanode Region Of Axon Postsynaptic Density Membrane Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Angiotensin-activated Signaling Pathway Cell Adhesion Focal Adhesion Assembly Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Potassium Ion Transport Cellular Component Assembly Plasma Membrane Protein Localization To Postsynaptic Membrane Adherens Junction Protein Localization To Postsynapse Regulation Of Heart Contraction Regulation Of Sodium Ion Transmembrane Transport Cell-substrate Junction Assembly Regulation Of Vesicle-mediated Transport Cell-substrate Junction Organization Regulation Of System Process Regulation Of Biological Quality Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Localization To Cell Periphery Receptor Localization To Synapse Regulation Of Cell Morphogenesis Receptor Clustering Regulation Of Blood Circulation Cell Junction Assembly Regulation Of Monoatomic Cation Transmembrane Transport Actin Filament Uncapping Protein Localization To Synapse P2Y1 Nucleotide Receptor Binding SUMO Conjugating Enzyme Activity Regulation Of Monoatomic Ion Transmembrane Transport Perinuclear Region Of Cytoplasm Epidermal Growth Factor Receptor Signaling Pathway Synaptic Membrane Regulation Of Multicellular Organismal Process Cytoskeletal Protein Binding Protein Localization To Membrane
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