PTPRE and KCNB1

Number of citations of the paper that reports this interaction (PMID 12615930)
22

Data Source:
HPRD (in vitro)

		PTPRE	KCNB1
Gene Name		protein tyrosine phosphatase, receptor type, E	potassium channel, voltage gated Shab related subfamily B, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Dendrite Dendrite Membrane Neuronal Cell Body Membrane Postsynaptic Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Homodimerization Activity	Delayed Rectifier Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Protein N-terminus Binding
	Biological Process	Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Regulation Of Mast Cell Activation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway	Energy Reserve Metabolic Process Synaptic Transmission Regulation Of Ion Transmembrane Transport Small Molecule Metabolic Process Regulation Of Insulin Secretion Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways			Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion Potassium Channels Voltage gated Potassium channels
Drugs
Diseases
GWAS		Response to amphetamines ( 22952603) Select biomarker traits ( 17903293)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: FYN GRB2 KCNA5 KCNB1 MAPK1 MAPK3 PTPRD PTPRS SRC YES1	14 interactors: KCNB2 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTPRE SNAP25 SRC STX1A
Entrez ID		5791	3745
HPRD ID		02956	08983
Ensembl ID		ENSG00000132334
Uniprot IDs		P23469 Q96P81	Q14721
PDB IDs		2JJD
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Hemostasis Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Response To Peptide Hormone Regulation Of Early Endosome To Late Endosome Transport Response To Platelet-derived Growth Factor Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway T Cell Costimulation Axonogenesis Cellular Response To Growth Factor Stimulus Axon Development Cellular Response To Hormone Stimulus Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Wound Healing Chemotaxis Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Positive Regulation Of Immune Response Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Cell Morphogenesis Involved In Differentiation Innate Immune Response Nervous System Development Neuron Projection Development	Potassium Ion Transmembrane Transport Potassium Ion Transport Synaptic Transmission Regulation Of Ion Transmembrane Transport Cell-cell Signaling Regulation Of Ion Transport Monovalent Inorganic Cation Transport Protein Homooligomerization Ion Transport Metal Ion Transport Protein Complex Assembly Protein Oligomerization Cation Transport Ion Transmembrane Transport Cation Transmembrane Transport Signaling Cell Communication Transmembrane Transport Cellular Component Assembly Transport Energy Reserve Metabolic Process Regulation Of Protein Secretion Regulation Of Protein Localization Regulation Of Caveolin-mediated Endocytosis Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Synaptic Vesicle Docking Regulation Of Hormone Secretion Regulation Of Cellular Localization Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Protein Transport Energy Derivation By Oxidation Of Organic Compounds Regulation Of Secretion Regulation Of Establishment Of Protein Localization Regulation Of Cellular Process Generation Of Precursor Metabolites And Energy Glutamate Secretion Regulation Of Membrane Depolarization Vesicle Fusion Synaptic Vesicle Exocytosis Regulation Of Membrane Potential Regulation Of Cell Junction Assembly Acid Secretion Vesicle Docking Involved In Exocytosis Regulation Of Insulin Receptor Signaling Pathway Regulation Of Signaling Organelle Fusion Regulation Of Cellular Response To Insulin Stimulus Vesicle Docking Dicarboxylic Acid Transport
Tagcloud ?		amplifications begin breakpoints copy csgalnact2 dataset dhx57 differing disruptions driver entity expand faf1 g34r h3f3a hgg icna intragenic k27m kcnd2 kidins220 map4k3 nf1 paediatric phgg rb1 ret suppressors tmem178	3xtg abundantly accordingly alanine argues c113s c73a caenorhabditis channels ectopic elegans exacerbated homolog insults invertebrate kv2 kvs mimics mutating neuropathy neuroprotective oligomerization oligomers oxidant oxidation oxidizing potassium protected underscore
Tagcloud (Difference) ?		amplifications begin breakpoints copy csgalnact2 dataset dhx57 differing disruptions driver entity expand faf1 g34r h3f3a hgg icna intragenic k27m kcnd2 kidins220 map4k3 nf1 paediatric phgg rb1 ret suppressors tmem178	3xtg abundantly accordingly alanine argues c113s c73a caenorhabditis channels ectopic elegans exacerbated homolog insults invertebrate kv2 kvs mimics mutating neuropathy neuroprotective oligomerization oligomers oxidant oxidation oxidizing potassium protected underscore
Tagcloud (Intersection) ?