DDX17 and FBL

Number of citations: 0 (PubMedID 10837141)
Data Source: HPRD (two hybrid, in vivo)

		DDX17	FBL
Name		DEAD-box helicase 17	fibrillarin
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Ribonucleoprotein Complex	Fibrillar Center Granular Component Nucleus Nucleoplasm Nucleolus Cajal Body Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Transcription Coactivator Activity RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity	TFIID-class Transcription Factor Complex Binding RNA Binding Protein Binding Methyltransferase Activity RRNA Methyltransferase Activity Transferase Activity ATPase Binding U6 SnRNA 2'-O-ribose Methyltransferase Activity Histone H2AQ104 Methyltransferase Activity
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Epithelial To Mesenchymal Transition Immune System Process Regulation Of Transcription By RNA Polymerase II RRNA Processing RNA Processing MRNA Processing RNA Splicing MiRNA Metabolic Process Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Regulatory NcRNA-mediated Gene Silencing Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Regulation Of Skeletal Muscle Cell Differentiation	Box C/D Sno(s)RNA 3'-end Processing Osteoblast Differentiation Chromatin Remodeling RRNA Processing Sno(s)RNA Metabolic Process RRNA Methylation Methylation Ribosomal Small Subunit Biogenesis SnoRNA Localization
Pathways		SUMOylation of transcription cofactors	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
GWAS		Hip index ( 34021172 ) Menopause (age at onset) ( 26414677 ) Resting heart rate ( 27798624 ) Sleep duration ( 30846698 )	No GWAS studies recorded
Interacting Genes		49 interacting genes: APBB1 APP BYSL CCDC187 CEBPA CREBBP CSNK2A1 DDX5 DDX6 DRC4 EGFR ESR1 FBL FOXP1 FXR2 GRB2 HADHB HDAC1 HNRNPH1 HNRNPH3 HNRNPK LNX1 NCOA1 NCOA2 NCOA3 OGT PIN1 PRPF6 PTK6 PTPRD RBM10 RBM14 RBM15 RBM4 RBM5 RBM7 SF1 SF3B4 SFPQ SNCA SNRNP70 SNRPA SORBS3 SREK1 SUMO2 USP7 WBP11 WBP2 YWHAG	21 interacting genes: DDX17 DDX5 ERG H2AC20 KLF6 MAP3K14 PIN4 PRMT1 PRMT3 PRMT6 PRMT8 PSMB6 PTEN RUVBL1 RUVBL2 SMN1 SMN2 SNRPN TAF9 TBC1D17 ZNF792
Entrez ID		10521	2091
HPRD ID		10532	00617
Ensembl ID		ENSG00000100201	ENSG00000105202
Uniprot IDs		A0A5H1ZRQ2 Q59F66 Q92841	P22087
PDB IDs		6UV0 6UV1 6UV2 6UV3 6UV4	2IPX 7MQ8 7MQ9 7MQA 7SE6 7SE7 7SE8 7SE9 7SEA 7SEB 7SEC 7SED
GO Terms Enriched among Interactors		Nucleoplasm MRNA Metabolic Process RNA Splicing RNA Binding RNA Metabolic Process Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process Spliceosomal Complex Regulation Of RNA Splicing RNA Processing Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Rhythmic Process Regulation Of MRNA Processing Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II MRNA Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Nuclear Speck Chromatin Remodeling Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription	Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Histone Methyltransferase Activity Box C/D SnoRNP Assembly Nucleoplasm Nucleus Chromatin Remodeling RNA Splicing Chromatin Organization Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Nucleic Acid Metabolic Process MLL1 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-arginine Methylation R2TP Complex Helicase Activity Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Histone H4 Methyltransferase Activity Telomerase RNA Localization To Cajal Body Regulation Of RNA Metabolic Process RNA Processing Methyltransferase Activity Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process TFIID-class Transcription Factor Complex Binding SMN Complex RPAP3/R2TP/prefoldin-like Complex Regulation Of Nucleobase-containing Compound Metabolic Process Methylation Gemini Of Cajal Bodies Swr1 Complex Positive Regulation Of DNA Recombination Positive Regulation Of Telomere Maintenance In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination ATPase Binding Ino80 Complex MRNA Processing Regulation Of DNA Repair Regulation Of DNA Strand Elongation Protein Stabilization SMN-Sm Protein Complex Regulation Of Gene Expression Dynein Axonemal Particle Positive Regulation Of Double-strand Break Repair